2230472-55-4
2230472-55-4
Chemical Structure
VGSC blocker-1
- CAS No.: 2230472-55-4
- Formula:C24H32F2N2
- Molecular Weight:386.52
IUPAC Name: 4,4-bis(4-fluorophenyl)-N-(3-(piperidin-1-yl)propyl)butan-1-amine
InChIKey: YHDCQGYFBMAZSX-UHFFFAOYSA-N
SMILES: FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCCCN3CCCCC3)C=C1
Biological Activity: VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability[1].
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VGSC blocker-1 | VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability. | |||||||||||||||||||||
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