1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. AR-R17779 hydrochloride

AR-R17779 hydrochloride 

Cat. No.: HY-135483A
Handling Instructions

AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways.

For research use only. We do not sell to patients.

AR-R17779 hydrochloride Chemical Structure

AR-R17779 hydrochloride Chemical Structure

CAS No. : 178419-42-6

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Description

AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways[1][2][4].

IC50 & Target

IC50: 92 nM (α7-nAChR)[1]

In Vitro

AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine for the α7 nicotinic receptor[1].
AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) ameliorates arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction[3].
AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen[3]
Dosage: 1, 2.5, 5 mg/kg
Administration: I.p. twice daily from day 20 until day 26
Result: Ameliorated arthritis and delayed onset of disease.
Reduced erosive disease, cartilage degradation and synovial inflammation.
Reduced TNFα levels in plasma and synovial tissue.
Molecular Weight

218.68

Formula

C₉H₁₅ClN₂O₂

CAS No.
SMILES

O=C(NC1)O[[email protected]@]21CN3CCC2CC3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AR-R17779nAChRNicotinic acetylcholine receptorsα7learningmemoryanxiolyticinflammationInhibitorinhibitorinhibit

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AR-R17779 hydrochloride
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HY-135483A
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