1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. AR-R17779 hydrochloride

AR-R17779 hydrochloride 

Cat. No.: HY-135483A
Handling Instructions

AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways.

For research use only. We do not sell to patients.

AR-R17779 hydrochloride Chemical Structure

AR-R17779 hydrochloride Chemical Structure

CAS No. : 178419-42-6

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Description

AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways[1][2][4].

IC50 & Target

IC50: 92 nM (α7-nAChR)[1]

In Vitro

AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine for the α7 nicotinic receptor[1].
AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) ameliorates arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction[3].
AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen[3]
Dosage: 1, 2.5, 5 mg/kg
Administration: I.p. twice daily from day 20 until day 26
Result: Ameliorated arthritis and delayed onset of disease.
Reduced erosive disease, cartilage degradation and synovial inflammation.
Reduced TNFα levels in plasma and synovial tissue.
Molecular Weight

218.68

Formula

C9H15ClN2O2

CAS No.
SMILES

O=C(NC1)O[[email protected]@]21CN3CCC2CC3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
AR-R17779 hydrochloride
Cat. No.:
HY-135483A
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