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  4. Mindeudesivir

Mindeudesivir  (Synonyms: JT001 free base; VV116 free base; GS-621763-d1)

Cat. No.: HY-145119S Purity: 99.02%
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GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119). GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice.

For research use only. We do not sell to patients.

Mindeudesivir Chemical Structure

Mindeudesivir Chemical Structure

CAS No. : 2647442-33-7

Size Price Stock Quantity
5 mg USD 280 In-stock
10 mg USD 440 In-stock
25 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Mindeudesivir:

Mindeudesivir Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119)[1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mindeudesivir Related Antibodies
Molecular Weight

502.54

Formula

C24H30DN5O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#C[C@](O[C@@H]1COC(C(C)C)=O)(C2=CC([2H])=C3N2N=CN=C3N)[C@@H]([C@@H]1OC(C(C)C)=O)OC(C(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9899 mL 9.9495 mL 19.8989 mL
5 mM 0.3980 mL 1.9899 mL 3.9798 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9899 mL 9.9495 mL 19.8989 mL 49.7473 mL
5 mM 0.3980 mL 1.9899 mL 3.9798 mL 9.9495 mL
10 mM 0.1990 mL 0.9949 mL 1.9899 mL 4.9747 mL
15 mM 0.1327 mL 0.6633 mL 1.3266 mL 3.3165 mL
20 mM 0.0995 mL 0.4975 mL 0.9949 mL 2.4874 mL
25 mM 0.0796 mL 0.3980 mL 0.7960 mL 1.9899 mL
30 mM 0.0663 mL 0.3316 mL 0.6633 mL 1.6582 mL
40 mM 0.0497 mL 0.2487 mL 0.4975 mL 1.2437 mL
50 mM 0.0398 mL 0.1990 mL 0.3980 mL 0.9949 mL
60 mM 0.0332 mL 0.1658 mL 0.3316 mL 0.8291 mL
80 mM 0.0249 mL 0.1244 mL 0.2487 mL 0.6218 mL
100 mM 0.0199 mL 0.0995 mL 0.1990 mL 0.4975 mL
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Mindeudesivir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mindeudesivir2647442-33-7JT001VV116 GS-621763-d1JT 001JT-001VV 116VV-116Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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