2647442-13-3
2647442-13-3
Chemical Structure
GS-621763
- CAS No.: 2647442-13-3
- Formula:C24H31N5O7
- Molecular Weight:501.53
IUPAC Name: (2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)
InChIKey: RVSSLHFYCSUAHY-JQGROFRJSA-N
SMILES: N#C[C@]1(C2=CC=C3N2N=CN=C3N)[C@@H]([C@@H]([C@H](O1)COC(C(C)C)=O)OC(C(C)C)=O)OC(C(C)C)=O
Biological Activity: GS-621763 is an orally available precursor to GS-441524 that exhibits anti-SARS-CoV-2 viral activity in mice. GS-621763 reduces viral load to undetectable levels in ferrets infected with SARS-CoV-2[1][2].
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GS-621763 | 99.72% | GS-621763 is an orally available precursor to GS-441524 that exhibits anti-SARS-CoV-2 viral activity in mice. GS-621763 reduces viral load to undetectable levels in ferrets infected with SARS-CoV-2. | ||||||||||||||||||||
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Mindeudesivir hydrobromide | 98.16% | Mindeudesivir (JT001; VV116; GS-621763-d1) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19. | ||||||||||||||||||||
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Mindeudesivir | 98.20% | GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119). GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice. | ||||||||||||||||||||
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References
- [1]. Schäfer A, et al. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111. [Content Brief]
- [2]. Cox RM, et al. Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets. Nat Commun. 2021 Nov 5;12(1):6415. [Content Brief]
