1. Anti-infection
  2. SARS-CoV
    RSV
    Influenza Virus
  3. VV116

VV116 (Synonyms: JT001; GS-621763-d1 hydrobromide)

Cat. No.: HY-145119AS Purity: 99.37%
Handling Instructions

VV116 (JT001) is an orally active nucleoside antiviral agent against SARS-CoV-2 and respiratory syncytial virus (RSV) infection. VV116 has favorable oral bioavailability, excellent in vitro antiviral activity and selectivity.

For research use only. We do not sell to patients.

VV116 Chemical Structure

VV116 Chemical Structure

Size Price Stock Quantity
5 mg USD 570 In-stock
Estimated Time of Arrival: December 31
10 mg USD 910 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1820 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2910 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

VV116 (JT001) is an orally active nucleoside antiviral agent against SARS-CoV-2 and respiratory syncytial virus (RSV) infection. VV116 has favorable oral bioavailability, excellent in vitro antiviral activity and selectivity[1][2].

IC50 & Target

SARS-CoV-2, RSV[1][2]

In Vitro

VV116 (0-1000 μM; 48 hours) can inhibit RSV replication in A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: A549 (infected with RSV)[1]
Concentration: 0-1000 μM
Incubation Time: 48 hours
Result: Inhibited RSV replication in A549 cells with EC50 of 1.20 ± 0.32 μM, CC50 of 95.92 ± 9.27 μM and selectivity index (SI) of 80.
In Vivo

VV116 (25, 50 and 100 mg/kg; PO; b.i.d for 4 days) exhibits a stronger activity and decreases the virus titers below the detection limit at 50 mg/kg, also reduces lung injury after RSV infection[1].
VV116 (25, 50 and 100 mg/kg; PO; single dosage) exhibits favorable PK properties and good safety profile[1].
Pharmacokinetic Parameters of VV116 (JT001) in Balb/c mice[1].

PO (25 mg/kg) PO (50 mg/kg) PO (100 mg/kg)
Tmax (h) 0.42 ± 0.14 0.42 ± 0.14 0.42 ± 0.14
Cmax (ng/mL) 5360 ± 560 11617 ± 3443 24017 ± 6521
AUC0-t (ng/mL·h) 11461 ± 1013 24594 ± 1059 47799 ± 6545
AUC0-∞ (ng/mL·h) 11534 ± 992 24739 ± 1028 48014 ± 6696
MRT0-∞ (ng/mL·h) 2.25 ± 0.32 2.15 ± 0.26 2.28 ± 0.53
Tmax (h) 2.30 ± 1.10 3.27 ± 1.92 4.25 ± 0.53

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice[1]
Dosage: 25, 50 and 100 mg/kg
Administration: PO; single dosage (Pharmacokinetics Analysis)
Result: Exhibited favorable PK properties and good safety profile.
Animal Model: Balb/c mice (6-8 weeks; intranasally infected with 4 × 10^6 FFU of RSV)[1]
Dosage: 25, 50 and 100 mg/kg
Administration: PO; b.i.d for 4 days
Result: Exhibited a stronger activity and decreased the virus titers below the detection limit at 50 mg/kg, also reduced lung injury after RSV infection.
Molecular Weight

583.45

Formula

C24H31DBrN5O7

SMILES

[H]Br.N#C[[email protected]](O[[email protected]@H]1COC(C(C)C)=O)(C2=CC([2H])=C3N2N=CN=C3N)[[email protected]@H]([[email protected]@H]1OC(C(C)C)=O)OC(C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (428.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7139 mL 8.5697 mL 17.1394 mL
5 mM 0.3428 mL 1.7139 mL 3.4279 mL
10 mM 0.1714 mL 0.8570 mL 1.7139 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.57 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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VV116
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