2. Anti-infection
  3. HCV
  4. GS-6620

GS-6620 is potent and selective HCV inhibitor. GS-6620 inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM. GS-6620 can be used for the researches of infection and inflammation, such as Hepatitis C Virus (HCV).

For research use only. We do not sell to patients.

GS-6620

GS-6620 Chemical Structure

CAS No. : 1350735-70-4

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Based on 1 publication(s) in Google Scholar

GS-6620 Related Antibodies

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Description

GS-6620 is potent and selective HCV inhibitor. GS-6620 inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM. GS-6620 can be used for the researches of infection and inflammation, such as Hepatitis C Virus (HCV)[1][2].

IC50 & Target[1]

GT3a

0.048 μM (EC50)

GT4a

0.11 μM (EC50)

GT6a

0.11 μM (EC50)

GT5a

0.14 μM (EC50)

GT1a

0.18 μM (EC50)

GT1b

0.46 μM (EC50)

GT2a

0.68 μM (EC50)

Cellular Effect
Cell Line Type Value Description References
HEp-2 CC50
95 μM
Compound: 13b
Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
[PMID: 28124907]
HeLa EC50
> 20 μM
Compound: 13b
Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay
Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay
[PMID: 28124907]
Huh-7 CC50
51 μM
Compound: 13b
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay
[PMID: 28124907]
MT4 CC50
7.8 μM
Compound: 13b
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
[PMID: 28124907]
In Vitro

GS-6620 (72 h) inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM and shows weak activity against bovine viral diarrhea virus (BVDV, EC50 = 1.5 μM)[1].
GS-6620 (active metabolite) (0.39-1.3 μM, 70-90 mins) inhibits HCV NS5B polymerase[1].
GS-6620 (0-100 μM, 5 days) shows low cytotoxicity in Huh-7, HepG2, PC-3 and PBMCs with CC50 values of 67, 66, 40 and >100 μM[1].
GS-6620 (20-100 μM, 5-10 days) does not reduce mitochondrial DNA content in HepG2 cells or inhibit mitochondrial protein synthesis in PC-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GS-6620 Related Antibodies
In Vivo

GS-6620 (1000 mg/kg for rats or 60 mg/kg for dogs, i.g., daily for 26-39 weeks) exerts no adverse effects in SD rats and beagle dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

644.61

Formula

C29H37N6O9P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=NN2C1=CC=C2[C@@]3(C#N)[C@@](O)(C)[C@H](OC(C(C)C)=O)[C@@H](CO[P@](OC4=CC=CC=C4)(N[C@@H](C)C(OC(C)C)=O)=O)O3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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GS-6620 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-66201350735-70-4GS6620GS 6620HCVHepatitis C virusVirusHCV NS5BHuh-7HepG2PC-3PBMCsInhibitorinhibitorinhibit

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