Bradanicline hydrochloride
Bradanicline (TC-5619) tosylate is an orally active agonist of α7 nAChR with moderate blood-brain barrier penetration. Bradanicline hydrochloride exhibits high affinity and subtype selectivity for human α7 nAChR. Bradanicline hydrochloride possesses antitussive activity that depends on sustained receptor binding and activation. Bradanicline hydrochloride requires systemic administration to dose-dependently inhibit cough induced by citric acid, bradykinin and inhaled nicotine. Bradanicline hydrochloride is well tolerated in preclinical studies and is widely used in research related to chronic refractory cough.
For research use only. We do not sell to patients.
- CAS No.: 1111941-90-2
- Formula: C22H24ClN3O2
- Molecular Weight:397.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 17 nM (human α7 nAChR) Ki: 1.4 nM (human α7 nAChR)
Bradanicline hydrochloride potently and selectively activates human α7 nAChRs in vitro, with an EC50 of 17 nM[1].
Bradanicline hydrochloride does not induce desensitization of α7 nAChRs in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Bradanicline (30 mg/kg; i.p.; 30 min prior to challenge) hydrochloride inhibits citric acid-induced cough in male Hartley guinea pigs, but shows no such effect when delivered directly to the airways via aerosol at a concentration of 3 mg/mL (concurrently with citric acid challenge)[1].
Bradanicline (30 mg/kg; i.p.; single administration; 30 minutes prior to challenge) hydrochloride inhibits bradykinin-induced cough in male Hartley guinea pigs[1].
Bradanicline (30 mg/kg; i.p.; single administration; 30 minutes prior to challenge) hydrochloride inhibits nicotine-induced cough in male Hartley guinea pigs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1111941-90-2
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Molecular Weight 397.90
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Formula C22H24ClN3O2
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SMILES
O=C(N[C@H]1[C@@H](N2CCC1CC2)CC3=CC=CN=C3)C4=CC5=CC=CC=C5O4.Cl
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Synonyms
TC-5619 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bradanicline hydrochloride Related Classifications
HY-18060A Related Classifications
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