1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Bradanicline

Bradanicline (Synonyms: TC-5619)

Cat. No.: HY-18060
Handling Instructions

Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC50=17 nM; Ki= 1.4 nM). Bradanicline is used for the research of cognitive disorders.

For research use only. We do not sell to patients.

Bradanicline Chemical Structure

Bradanicline Chemical Structure

CAS No. : 639489-84-2

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Description

Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC50=17 nM; Ki= 1.4 nM). Bradanicline is used for the research of cognitive disorders[1][2].

In Vitro

Bradanicline is more than a thousand-fold separation between the affinities for the α7 and α4β2 receptor subtypes and has no detectable effects on muscle or ganglionic nicotinic receptor subtypes, indicating a marked selectivity for the central nervous system over the peripheral nervous system[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bradanicline (0.1-1 mg/kg) shows efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

361.44

Formula

C₂₂H₂₃N₃O₂

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Bradanicline
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HY-18060
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