2. Immunology/Inflammation
  3. IFNAR
  4. Sifalimumab

Sifalimumab  (Synonyms: MEDI-545; MDX 1103)

Cat. No.: HY-P99219 Purity: 98.55%
COA

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Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research.

For research use only. We do not sell to patients.

Sifalimumab Chemical Structure

Sifalimumab Chemical Structure

CAS No. : 1006877-41-3

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5 mg USD 938 In-stock
10 mg USD 1500 In-stock
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Sifalimumab Related Antibodies

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Description

Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research[1][2].

In Vitro

Sifalimumab (3-36 μg/well; 72 h) attenuates lymphocyte cytotoxicity co-cultured with U-87MG[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sifalimumab Related Antibodies

Cell Viability Assay[2]

Cell Line: U-87MG cells and AGS lymphocytes
Concentration: 3-36 μg/well
Incubation Time: 72 hours
Result: Attenuated lymphocyte cytotoxicity triggered by IFN I (P<0.05).
In Vivo

Sifalimumab (subcutaneous injection; 30 mg/kg and 3 μg/g) treatment shows therapeutic effect and attenuates the lymphocyte infiltration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type male BALB/c mice[2]
Dosage: 30 mg/kg and 3 μg/g
Administration: Subcutaneous injection; 30 mg/kg and 3 μg/g
Result: Prevented the increase CpG-induced, decreasing CD86 fluorescence intensity by 1.9-fold (P < 0.05).
Showed a potentially therapeutic effect attenuating the CpG-induced lymphocyte infiltration.
Attenuated the CD45 increase (P<0.05).
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Sifalimumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.55%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Sifalimumab Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sifalimumab1006877-41-3MEDI-545 MDX 1103MEDI545MEDI 545MDX1103MDX 1103MDX-1103IFNARInterferon-α/β receptorInterferon-alpha/beta receptorsystemic lupus erythematosusSLEU-87MG cellAGS lymphocytesInhibitorinhibitorinhibit

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