2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK2-IN-18

CDK2-IN-18 (compound 8q) is a potent inhibitor of CDK2/E and CDK4/D1, with IC50s of 8 nM and 46 nM, respectively. CDK2-IN-18 inhibits the proliferation of tumor cells.

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CDK2-IN-18

CDK2-IN-18 Chemical Structure

CAS No. : 364735-73-9

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CDK2-IN-18 Related Antibodies

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Description

CDK2-IN-18 (compound 8q) is a potent inhibitor of CDK2/E and CDK4/D1, with IC50s of 8 nM and 46 nM, respectively. CDK2-IN-18 inhibits the proliferation of tumor cells[1].

IC50 & Target

CDK2/cyclinE

8 nM (IC50)

Cdk4/cyclin D1

46 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
AG1523 IC50
> 21000 nM
Compound: 8q
Inhibition of AG1523 (arrested) cell proliferation
Inhibition of AG1523 (arrested) cell proliferation
[PMID: 14698155]
AG1523 IC50
> 21000 nM
Compound: 8q
Inhibition of proliferation AG1523 (human fibroblast) cell line.
Inhibition of proliferation AG1523 (human fibroblast) cell line.
[PMID: 14698155]
B16 IC50
160 nM
Compound: 8q
Inhibition of B16-F1 cell proliferation
Inhibition of B16-F1 cell proliferation
[PMID: 14698155]
HCT-116 IC50
14 nM
Compound: 8q
Inhibition of HCT116 cellular proliferation
Inhibition of HCT116 cellular proliferation
[PMID: 14698155]
HCT-116 IC50
260 nM
Compound: 8q
Inhibition of HCT116 cell proliferation in the presence of human serum albumin and alpha-1-acidglycoprotein
Inhibition of HCT116 cell proliferation in the presence of human serum albumin and alpha-1-acidglycoprotein
[PMID: 14698155]
HMEC IC50
55 nM
Compound: 8q
Inhibition of HMEC cell proliferation
Inhibition of HMEC cell proliferation
[PMID: 14698155]
HT-1080 IC50
30 nM
Compound: 8q
Inhibition of HT1080 cell proliferation
Inhibition of HT1080 cell proliferation
[PMID: 14698155]
HT-29 IC50
87 nM
Compound: 8q
Inhibition of HT-29 cell proliferation
Inhibition of HT-29 cell proliferation
[PMID: 14698155]
L1210 IC50
105 nM
Compound: 8q
Inhibition of L1210 cell proliferation
Inhibition of L1210 cell proliferation
[PMID: 14698155]
MCF7 IC50
23 nM
Compound: 8q
Inhibition of MCF-7 cell proliferation
Inhibition of MCF-7 cell proliferation
[PMID: 14698155]
MIA PaCa-2 IC50
26 nM
Compound: 8q
Inhibition of MiaPaCa2 cell proliferation
Inhibition of MiaPaCa2 cell proliferation
[PMID: 14698155]
NCI-H1299 IC50
12 nM
Compound: 8q
Inhibition of H1299 cell proliferation
Inhibition of H1299 cell proliferation
[PMID: 14698155]
NCI-H358 IC50
18 nM
Compound: 8q
Inhibition of NCI-H358 cell proliferation
Inhibition of NCI-H358 cell proliferation
[PMID: 14698155]
NCI-H460 IC50
104 nM
Compound: 8q
Inhibition of NCI-H460 cell proliferation
Inhibition of NCI-H460 cell proliferation
[PMID: 14698155]
PC-3 IC50
125 nM
Compound: 8q
Inhibition of PC3 cell proliferation
Inhibition of PC3 cell proliferation
[PMID: 14698155]
SKUT-1A IC50
25 nM
Compound: 8q
Inhibition of Skut 1A cell proliferation
Inhibition of Skut 1A cell proliferation
[PMID: 14698155]
Molecular Weight

437.52

Formula

C21H23N7O2S
CAS No.
SMILES

O=C(NN1CCN(CC1)C)NC2=CC=CC(C3=NNC(C4=C(C)N=C(C)S4)=C35)=C2C5=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK2-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-18364735-73-9CDKCyclin dependent kinaseHT29 cellsHT1080 cellstumorInhibitorinhibitorinhibit

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