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Cat. No.: HY-155602

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CDK2-IN-18

CDK2-IN-18 (compound 8q) is a potent inhibitor of CDK2/E and CDK4/D1, with IC₅₀s of 8 nM and 46 nM, respectively. CDK2-IN-18 inhibits the proliferation of tumor cells.

For research use only. We do not sell to patients.

CAS No.: 364735-73-9
Formula: C₂₁H₂₃N₇O₂S
Molecular Weight:437.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CDK2-IN-18 Chemical Structure

CAS No.: 364735-73-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CDK2-IN-18 (compound 8q) is a potent inhibitor of CDK2/E and CDK4/D1, with IC₅₀s of 8 nM and 46 nM, respectively. CDK2-IN-18 inhibits the proliferation of tumor cells^[1].

IC₅₀ & Target

CDK2/cyclinE

8 nM (IC₅₀)

Cdk4/cyclin D1

46 nM (IC₅₀)

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
AG1523	IC₅₀	>21000 nM Compound: 8q	Inhibition of proliferation AG1523 (human fibroblast) cell line. Inhibition of proliferation AG1523 (human fibroblast) cell line.	[PMID: 14698155]
AG1523	IC₅₀	>21000 nM Compound: 8q	Inhibition of AG1523 (arrested) cell proliferation Inhibition of AG1523 (arrested) cell proliferation	[PMID: 14698155]
B16	IC₅₀	160 nM Compound: 8q	Inhibition of B16-F1 cell proliferation Inhibition of B16-F1 cell proliferation	[PMID: 14698155]
HCT-116	IC₅₀	14 nM Compound: 8q	Inhibition of HCT116 cellular proliferation Inhibition of HCT116 cellular proliferation	[PMID: 14698155]
HCT-116	IC₅₀	260 nM Compound: 8q	Inhibition of HCT116 cell proliferation in the presence of human serum albumin and alpha-1-acidglycoprotein Inhibition of HCT116 cell proliferation in the presence of human serum albumin and alpha-1-acidglycoprotein	[PMID: 14698155]
HMEC	IC₅₀	55 nM Compound: 8q	Inhibition of HMEC cell proliferation Inhibition of HMEC cell proliferation	[PMID: 14698155]
HT-1080	IC₅₀	30 nM Compound: 8q	Inhibition of HT1080 cell proliferation Inhibition of HT1080 cell proliferation	[PMID: 14698155]
HT-29	IC₅₀	87 nM Compound: 8q	Inhibition of HT-29 cell proliferation Inhibition of HT-29 cell proliferation	[PMID: 14698155]
L1210	IC₅₀	105 nM Compound: 8q	Inhibition of L1210 cell proliferation Inhibition of L1210 cell proliferation	[PMID: 14698155]
MCF7	IC₅₀	23 nM Compound: 8q	Inhibition of MCF-7 cell proliferation Inhibition of MCF-7 cell proliferation	[PMID: 14698155]
MIA PaCa-2	IC₅₀	26 nM Compound: 8q	Inhibition of MiaPaCa2 cell proliferation Inhibition of MiaPaCa2 cell proliferation	[PMID: 14698155]
NCI-H1299	IC₅₀	12 nM Compound: 8q	Inhibition of H1299 cell proliferation Inhibition of H1299 cell proliferation	[PMID: 14698155]
NCI-H358	IC₅₀	18 nM Compound: 8q	Inhibition of NCI-H358 cell proliferation Inhibition of NCI-H358 cell proliferation	[PMID: 14698155]
NCI-H460	IC₅₀	104 nM Compound: 8q	Inhibition of NCI-H460 cell proliferation Inhibition of NCI-H460 cell proliferation	[PMID: 14698155]
PC-3	IC₅₀	125 nM Compound: 8q	Inhibition of PC3 cell proliferation Inhibition of PC3 cell proliferation	[PMID: 14698155]
SKUT-1A	IC₅₀	25 nM Compound: 8q	Inhibition of Skut 1A cell proliferation Inhibition of Skut 1A cell proliferation	[PMID: 14698155]

Chemical Information

CAS No. 364735-73-9
Molecular Weight 437.52
Formula C₂₁H₂₃N₇O₂S
SMILES

O=C(NN1CCN(CC1)C)NC2=CC=CC(C3=NNC(C4=C(C)N=C(C)S4)=C35)=C2C5=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Eddy W Yue, et al. Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3. Bioorg Med Chem Lett. 2004 Jan 19;14(2):343-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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CDK2-IN-18

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CDK2-IN-18 Related Classifications

HY-155602 Related Classifications