1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Rac-VU 6008667

Rac-VU 6008667 

Cat. No.: HY-101281A
Handling Instructions

Rac-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration.

For research use only. We do not sell to patients.

Rac-VU 6008667 Chemical Structure

Rac-VU 6008667 Chemical Structure

CAS No. : 2092917-63-8

Size Price Stock
1 mg USD 60 Ask For Quote & Lead Time
5 mg USD 180 Ask For Quote & Lead Time
10 mg USD 330 Ask For Quote & Lead Time
25 mg USD 750 Ask For Quote & Lead Time
50 mg USD 1350 Ask For Quote & Lead Time
100 mg USD 2250 Ask For Quote & Lead Time

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Description

Rac-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration[1].

IC50 & Target

IC50: 1.8 μM (M5)[1]

Molecular Weight

438.85

Formula

C₂₄H₁₇ClF₂N₂O₂

CAS No.

2092917-63-8

SMILES

O=C1N2C(N(C(C3=CC=C(F)C(F)=C3)=O)CC2)(C4=CC=C(Cl)C(C)=C4)C5=C1C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (284.84 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2787 mL 11.3934 mL 22.7868 mL
5 mM 0.4557 mL 2.2787 mL 4.5574 mL
10 mM 0.2279 mL 1.1393 mL 2.2787 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product name:
Rac-VU 6008667
Cat. No.:
HY-101281A
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