1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Rac-VU 6008667

Rac-VU 6008667 

Cat. No.: HY-101281A
Handling Instructions

Rac-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. Rac-VU 6008667 has high CNS penetration. M5 NAM: muscarinic acetylcholine receptor subtype 5.

For research use only. We do not sell to patients.

Rac-VU 6008667 Chemical Structure

Rac-VU 6008667 Chemical Structure

CAS No. : 2092917-63-8

Size Price Stock
5 mg USD 350 Ask For Quote & Lead Time
10 mg USD 550 Ask For Quote & Lead Time
50 mg USD 1650 Ask For Quote & Lead Time
100 mg USD 2250 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Other Forms of Rac-VU 6008667:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Rac-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. Rac-VU 6008667 has high CNS penetration[1]. M5 NAM: muscarinic acetylcholine receptor subtype 5.

IC50 & Target

IC50: 1.2 μM (Human M5); 1.6 μM (Rat M5)[1]

Molecular Weight

438.85

Formula

C₂₄H₁₇ClF₂N₂O₂

CAS No.

2092917-63-8

SMILES

O=C1N2C(N(C(C3=CC=C(F)C(F)=C3)=O)CC2)(C4=CC=C(Cl)C(C)=C4)C5=C1C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

氘代氯仿 : ≥ 125 mg/mL (284.84 mM)

DMSO : 125 mg/mL (284.84 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2787 mL 11.3934 mL 22.7868 mL
5 mM 0.4557 mL 2.2787 mL 4.5574 mL
10 mM 0.2279 mL 1.1393 mL 2.2787 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Rac-VU 6008667
Cat. No.:
HY-101281A
Quantity: