2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HYF031

HYF031 is a selective, blood-brain barrier-permeable HDAC8 inhibitor with an IC50 of 5.7 nM, and exhibits extremely low activity against most other HDAC subtypes. HYF031 is applicable for HDAC8 imaging studies.

For research use only. We do not sell to patients.

HYF031

HYF031 Chemical Structure

CAS No. : 1417997-91-1

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HYF031 Related Antibodies

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View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HYF031 is a selective, blood-brain barrier-permeable HDAC8 inhibitor with an IC50 of 5.7 nM, and exhibits extremely low activity against most other HDAC subtypes. HYF031 is applicable for HDAC8 imaging studies[1].

IC50 & Target[1]

HDAC8

5.7 nM (IC50)

In Vivo

[11C]HYF031 (5.55-7.40 MBq; intravenous injection; single dose) exhibits detectable brain penetration, pharmacokinetic properties suitable for PET imaging, specific binding to HDAC8 in mouse brains, and is primarily metabolized via the hepatobiliary pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

348.19

Formula

C16H14BrNO3
CAS No.
SMILES

COC1=CC=C(C(C2=CC=C(C=C2)Br)=C1)/C=C/C(NO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HYF031 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HYF0311417997-91-1HYF 031HYF-031HDACHistone deacetylasesHDAC8HDAC isoformsblood-brain barriermouse brainPET imaginghepatobiliary metabolismneurodegenerative diseasesInhibitorinhibitorinhibit

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