Dulaglutide (Synonyms: LY2189265)

Name: Dulaglutide
Brand: MedChemExpress
SKU: HY-P0120
Rating: 4.5 (1 reviews)

Cat. No.: HY-P0120 Purity: 96%: Data Sheet
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Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) .

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 923950-08-7

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Dulaglutide:

GLP-1 moiety from Dulaglutide In-stock

1 Publications Citing Use of MCE Dulaglutide

•Endocrinol Metab. 2022 Feb;37(1):74-83. [Abstract]

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: Dulaglutide purchased from MedChemExpress. Usage Cited in: Endocrinol Metab. 2022 Feb;37(1):74-83. [Abstract]; Dulaglutide (Dula) inhibits palmitic acid (PA)-induced lipid accumulation in HepG2 cells. Cells were pre-treated with 400 μM PA for 24 hours, followed by treatment with or without 100 nM Dula for 24 hours. Lipid accumulation were evaluated using Oil red O staining.

: Dulaglutide purchased from MedChemExpress. Usage Cited in: Endocrinol Metab. 2022 Feb;37(1):74-83. [Abstract]; Dula glycopeptide (Dula) reduced lipogenesis and triglyceride (TG) synthesis in palmitic acid (PA)-treated HepG2 cells and increased TG secretion. HepG2 cells were pretreated with 400 μM PA for 24 hours, followed by treatment with or without 100 nM Dula for 24 hours. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the mRNA expression levels of genes encoding sterol regulatory binding protein 1 (SREBP-1), acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS).

: Dulaglutide purchased from MedChemExpress. Usage Cited in: Endocrinol Metab. 2022 Feb;37(1):74-83. [Abstract]; Cells were pre-treated with 400 μM PA for 24 hours, followed by treatment with or without 100 nM Dulaglutide and 100 nM exendin (9–39), a GLP-1R antagonist, for 24 hours. FAM3A, GLP-1R, sirtuin 1 (SIRT1), phospho-adenosine monophosphate-activated protein kinase (p-AMPK), phospho-acetyl-CoA carboxylase (p-ACC), and peroxisome proliferator-activated receptor alpha (PPARα) levels were analyzed using Western blotting.

: Dulaglutide purchased from MedChemExpress. Usage Cited in: Endocrinol Metab. 2022 Feb;37(1):74-83. [Abstract]; Dulaglutide (Dula) inhibits lipid deposition and increases fatty acid oxidation via family with sequence similarity 3 member A (FAM3A). HepG2 cells transfected with 10 nM FAM3A small interfering RNA (siRNA) or control (Con) siRNA for 24 hours were pretreated with 400 μM palmitic acid (PA) for 24 hours, followed by treatment with or without 100 nM Dula for 24 hours. Lipid deposition was evaluated using triglyceride (TG) content assay.

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Description

Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) ^[1]^[2].

IC₅₀ & Target

GLP-1 receptor^[1]

In Vitro

Dulaglutide (50 nM and 100 nM; 24 h) ameliorates ox-LDL-induced oxidative stress and suppresses ox-LDL-induced mitochondrial dysfunction in human aortic endothelial cells (HAECs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Human aortic endothelial cells (HAECs)
Concentration:	50 nM, 100 nM
Incubation Time:	24 hous
Result:	Suppressed ox-LDL-induced reduction of cell viability and release of lactate dehydrogenase (LDH).

In Vivo

Dulaglutide (0, 0.05, 0.5, 1.5, or 5 mg/kg; s.c.; twice week, for 93 weeks) increases the incidence of thyroid C-cell hyperplasia and neoplasia in the rat carcinogenicity study^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats and Transgenic mice^[1]
Dosage:	0, 0.05, 0.5, 1.5, or 5 mg/kg; 0, 0.3, 1, or 3 mg/kg
Administration:	SC, twice week, for 93 weeks; SC, twice week, for 26 weeks
Result:	Statistically increased diffuse C-cell hyperplasia and adenomas at ＞0.5 mg/kg. Decreased Systemic exposures over time in mice.

Clinical Trial

Molecular Weight

62561 (Glycosylation, Dominant form)

CAS No.

923950-08-7

Appearance

Liquid

Color

Colorless to light yellow

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at 4°C, do not freeze

Purity & Documentation

Purity: 96%

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Data Sheet (271 KB) SDS (252 KB)

COA (232 KB)

Handling Instructions (2659 KB)

References

[1]. Chang W, et al. Glucagon-like peptide-1 receptor agonist dulaglutide prevents ox-LDL-induced adhesion of monocytes to human endothelial cells: An implication in the treatment of atherosclerosis. Mol Immunol. 2019 Dec;116:73-79. [Content Brief]

[2]. Hertzel C Gerstein, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. Lancet [Content Brief]

[3]. Byrd RA, et al. Chronic Toxicity and Carcinogenicity Studies of the Long-Acting GLP-1 Receptor AgonistDulaglutide in Rodents. Endocrinology. 2015 Jul;156(7):2417-28. [Content Brief]

Dulaglutide Related Classifications

Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dulaglutide923950-08-7LY2189265LY 2189265LY-2189265GCGRGlucagon Receptorglucagon-like peptide-1 (GLP-1)receptor type 2 diabetes (T2D)Inhibitorinhibitorinhibit

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Dulaglutide (Synonyms: LY2189265)

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Other Forms of Dulaglutide:

Dulaglutide Related Antibodies

1 Publications Citing Use of MCE Dulaglutide

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