1. Dulaglutide

Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) .

For research use only. We do not sell to patients.

Dulaglutide Chemical Structure

Dulaglutide Chemical Structure

CAS No. : 923950-08-7

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Description

Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) [1][2].

IC50 & Target

GLP-1 receptor[1]

In Vitro

Dulaglutide (50 nM and 100 nM; 24 h) ameliorates ox-LDL-induced oxidative stress and suppresses ox-LDL-induced mitochondrial dysfunction in human aortic endothelial cells (HAECs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human aortic endothelial cells (HAECs)
Concentration: 50 nM, 100 nM
Incubation Time: 24 hous
Result: Suppressed ox-LDL-induced reduction of cell viability and release of lactate dehydrogenase (LDH).
In Vivo

Dulaglutide (0, 0.05, 0.5, 1.5, or 5 mg/kg; s.c.; twice week, for 93 weeks) increases the incidence of thyroid C-cell hyperplasia and neoplasia in the rat carcinogenicity study[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats and Transgenic mice[1]
Dosage: 0, 0.05, 0.5, 1.5, or 5 mg/kg; 0, 0.3, 1, or 3 mg/kg
Administration: SC, twice week, for 93 weeks; SC, twice week, for 26 weeks
Result: Statistically increased diffuse C-cell hyperplasia and adenomas at >0.5 mg/kg.
Decreased Systemic exposures over time in mice.
Clinical Trial
CAS No.
SMILES

[Dulaglutide]

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Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dulaglutide
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HY-P0120
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