2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. GX-936

GX-936 (PF-05196233), a potent and Nav1.7-subtype selective inhibitor, binds to the activated state of voltage-sensor domain IV (VSD4).

For research use only. We do not sell to patients.

GX-936

GX-936 Chemical Structure

CAS No. : 1235406-09-3

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Based on 1 publication(s) in Google Scholar

GX-936 Related Antibodies

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Description

GX-936 (PF-05196233), a potent and Nav1.7-subtype selective inhibitor, binds to the activated state of voltage-sensor domain IV (VSD4)[1][2][3].

Molecular Weight

575.59

Formula

C24H20F3N7O3S2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=S(C1=CC=C(C(C#N)=C1)OC2=CC=C(C=C2C3=CC=NN3C4CN(C4)CC)C(F)(F)F)(NC5=NC=NS5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 75 mg/mL (130.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7373 mL 8.6867 mL 17.3735 mL
5 mM 0.3475 mL 1.7373 mL 3.4747 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7373 mL 8.6867 mL 17.3735 mL 43.4337 mL
5 mM 0.3475 mL 1.7373 mL 3.4747 mL 8.6867 mL
10 mM 0.1737 mL 0.8687 mL 1.7373 mL 4.3434 mL
15 mM 0.1158 mL 0.5791 mL 1.1582 mL 2.8956 mL
20 mM 0.0869 mL 0.4343 mL 0.8687 mL 2.1717 mL
25 mM 0.0695 mL 0.3475 mL 0.6949 mL 1.7373 mL
30 mM 0.0579 mL 0.2896 mL 0.5791 mL 1.4478 mL
40 mM 0.0434 mL 0.2172 mL 0.4343 mL 1.0858 mL
50 mM 0.0347 mL 0.1737 mL 0.3475 mL 0.8687 mL
60 mM 0.0290 mL 0.1448 mL 0.2896 mL 0.7239 mL
80 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.5429 mL
100 mM 0.0174 mL 0.0869 mL 0.1737 mL 0.4343 mL
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GX-936 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GX-9361235406-09-3PF-05196233GX936GX 936PF05196233PF 05196233Sodium ChannelNa channelsNa+ channelsNav1.7VSD4Inhibitorinhibitorinhibit

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