2. Anti-infection
  3. HBV
  4. Brelovitug

Brelovitug  (Synonyms: BJT-778)

Cat. No.: HY-P991674 Purity: 99%
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Brelovitug (BJT-778) is a humanized IgG1 neutralizing monoclonal antibody targeting hepatitis B surface antigen (HBsAg). Brelovitug binds with high affinity to HBsAg purified from HBV serotypes ad and ay, with Kd values of 0.22 nM and 0.39 nM, respectively. Brelovitug binds with high affinity to HBsAg of HBV genotypes A, B, C and D, with IC50 values of 0.07, 0.02, 0.02 and 0.07 nM, respectively. Brelovitug can be used in research related to chronic hepatitis B and chronic hepatitis D.

For research use only. We do not sell to patients.

CAS No. : 3033337-14-0

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Brelovitug Related Antibodies

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Description

Brelovitug (BJT-778) is a humanized IgG1 neutralizing monoclonal antibody targeting hepatitis B surface antigen (HBsAg). Brelovitug binds with high affinity to HBsAg purified from HBV serotypes ad and ay, with Kd values of 0.22 nM and 0.39 nM, respectively. Brelovitug binds with high affinity to HBsAg of HBV genotypes A, B, C and D, with IC50 values of 0.07, 0.02, 0.02 and 0.07 nM, respectively. Brelovitug can be used in research related to chronic hepatitis B and chronic hepatitis D[1].

Isotype

Human IgG1 lambda2
Recommend Isotype Controls
IC50 & Target

HbsAg
In Vitro

Brelovitug binds to wild-type and clinically mutated HBsAg (D144A, T126S, M133L) with IC50 values ranging from 0.03 to 0.99 nM, but does not bind to HBsAg bearing the G145R mutation[1].
Brelovitug (8 days) potently neutralizes HBV infection in primary human hepatocytes, with EC50 values of 0.09 nM for HBsAg inhibition and 0.11 nM for HBeAg inhibition[1].
Brelovitug (8 days) potently neutralizes HDV infection in HBV/HDV co-infected primary human hepatocytes, with an EC50 value of 0.01 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Brelovitug Related Antibodies
In Vivo

BJT-778 (20 mg/kg; i.p.; dosed on day 0 and day 21) rapidly depletes serum HBsAg and maintains depletion for up to 14 days in a humanized FRG mouse model of chronic HBV infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fah/Rag2/IL-2rγ triple knockout (FRG) (humanized, chronic HBV infection model)[1]
Dosage: 20 mg/kg
Administration: i.p.; dosed on day 0 and day 21
Result: Rapidly depleted serum HBsAg and maintained HBsAg depletion for up to 14 days post-dosing.
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

143.954 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

N/A
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-lambda
Purity & Documentation
References
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Brelovitug Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brelovitug3033337-14-0BJT-778BJT778BJT 778HBVHepatitis B viruschronic hepatitis Bchronic hepatitis DFc-gammaT cellprimary human hepatocytesHepatitis B surface antigenHDVhumanized FRG mouse modelHBsAgInhibitorinhibitorinhibit

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