JNJ 2408068 (Synonyms: R170591)

Cat. No.: HY-11098: FAQs
Data Sheet SDS COA Handling Instructions

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JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ 2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg.

For research use only. We do not sell to patients.

JNJ 2408068 Chemical Structure

CAS No. : 317846-22-3

Size	Price	Stock
1 mg	USD 190	Ask For Quote & Lead Time
5 mg	USD 460	Ask For Quote & Lead Time
10 mg	USD 740	Ask For Quote & Lead Time
25 mg	USD 1450	Ask For Quote & Lead Time
50 mg	USD 2350	Ask For Quote & Lead Time
100 mg	USD 3800	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Purity & Documentation
References
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Description

Molecular Weight

394.51

Formula

C₂₂H₃₀N₆O

CAS No.

317846-22-3

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C)N=C1CN2C3=CC=CC(C)=C3N=C2NC4CCN(CCN)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (253.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5348 mL	12.6740 mL	25.3479 mL
5 mM	0.5070 mL	2.5348 mL	5.0696 mL
10 mM	0.2535 mL	1.2674 mL	2.5348 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.34 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (6.34 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 96.57%

Select Batch:

Data Sheet (275 KB) SDS (0 KB)

COA (254 KB) HNMR (143 KB) RP-HPLC (165 KB) LCMS (382 KB)

Handling Instructions (2659 KB)

References

[1]. Wyde PR, et al. Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection. Antiviral Res. 2003 Nov;60(3):221-31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5348 mL	12.6739 mL	25.3479 mL	63.3697 mL
	5 mM	0.5070 mL	2.5348 mL	5.0696 mL	12.6739 mL
	10 mM	0.2535 mL	1.2674 mL	2.5348 mL	6.3370 mL
	15 mM	0.1690 mL	0.8449 mL	1.6899 mL	4.2246 mL
	20 mM	0.1267 mL	0.6337 mL	1.2674 mL	3.1685 mL
	25 mM	0.1014 mL	0.5070 mL	1.0139 mL	2.5348 mL
	30 mM	0.0845 mL	0.4225 mL	0.8449 mL	2.1123 mL
	40 mM	0.0634 mL	0.3168 mL	0.6337 mL	1.5842 mL
	50 mM	0.0507 mL	0.2535 mL	0.5070 mL	1.2674 mL
	60 mM	0.0422 mL	0.2112 mL	0.4225 mL	1.0562 mL
	80 mM	0.0317 mL	0.1584 mL	0.3168 mL	0.7921 mL
	100 mM	0.0253 mL	0.1267 mL	0.2535 mL	0.6337 mL

JNJ 2408068 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ 2408068317846-22-3R170591JNJ2408068JNJ-2408068R 170591R-170591RSVRespiratory syncytial virusAntiviralCotton ratsAerosolInhibitorinhibitorinhibit

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