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Cat. No.: HY-176236

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Lipophagy inducer 1

Lipophagy inducer 1 is a lipophagy inducer. Lipophagy inducer 1 has activity of reducing lipid droplet accumulation and rescuing cell death. Lipophagy inducer 1 exerts its effects by activating lipophagy, increasing steady-state autophagosome and regulating the LXR signaling pathway. Lipophagy inducer 1 can be used in the study of diabetic nephropathy (DKD) and other diseases related to lipid metabolism disorders.

For research use only. We do not sell to patients.

Formula: C₂₅H₄₆N₄O
Molecular Weight:418.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Lipophagy inducer 1 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Lipophagy inducer 1 (Compound 2726.007) reduces lipid droplet accumulation and restores cell viability in puromycin-stressed differentiated human podocytes^[1].
Lipophagy inducer 1 (1-10 μM) exhibits no agonist activity at any tested adrenergic receptor subtype^[1].
Lipophagy inducer 1 significantly increases steady-state autophagosome numbers in differentiated human podocytes^[1].
Lipophagy inducer 1 attenuates lipid droplet accumulation in puromycin-stressed differentiated human podocytes via induction of lipophagy, as its effect is blocked by the LAL inhibitor Lalistat^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 418.66
Formula C₂₅H₄₆N₄O
SMILES

O=C1N(CC)[C@H]([C@H](C)CC)CN1CCCC[C@H]2CN=C(CCCC3CCCCC3)N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Njeim R, et al. Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism Disorders. ACS Chem Biol. 2025;20(6):1406-1416. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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