BRD4 D1-IN-2
BRD4 D1-IN-2 (compound 26) is a potent and selective BRD4 D1 inhibitor (IC50<0.092 µM). BRD4 D1-IN-2 has 15 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC.
For research use only. We do not sell to patients.
- CAS No.: 2863687-22-1
- Formula: C33H39F3N6O
- Molecular Weight:592.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRD4 BD1 <0.092 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
3.6 μM
Compound: 26
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Cytotoxicity against human A549 cells assessed as viable cells incubated for 23 hrs by alamar blue assay
Cytotoxicity against human A549 cells assessed as viable cells incubated for 23 hrs by alamar blue assay
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[PMID: 35007061] |
Chemical Information
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CAS No. 2863687-22-1
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Molecular Weight 592.70
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Formula C33H39F3N6O
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SMILES
CC(C1=CC=C(C(OC2=NC(C3=C(N=CN3C4CCN(CC4)CCN(C)C)C5=CC=C(C=C5)C(F)(F)F)=CC=N2)=C1)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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