(R)-JAK2/STAT3-IN-1
(R)-JAK2/STAT3-IN-1 is a GP130 D1 domain inhibitor with anti-tumor activity. (R)-JAK2/STAT3-IN-1 can inhibit the phosphorylation of JAK2 and STAT3. The affinity of (R)-JAK2/STAT3-IN-1 for GP130 protein is 3.8 μM. (R)-JAK2/STAT3-IN-1 effectively inhibits the viability and migration of tumor cells and promotes apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2485758-49-2
- Formula: C34H35BrF3N5O2
- Molecular Weight:682.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
6.16 μM
Compound: (R)-10a
|
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
|
[PMID: 32388278] |
Chemical Information
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CAS No. 2485758-49-2
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Molecular Weight 682.57
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Formula C34H35BrF3N5O2
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SMILES
NC(N1[C@H](CC(C2=CC=C(C=C2)C(F)(F)F)=N1)C(C3=C4)=CN(CC5=CC=C(C=C5)OCCN6CCCCCC6)C3=CC=C4Br)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)