2485758-49-2
2485758-49-2
Chemical Structure
(R)-JAK2/STAT3-IN-1
- CAS No.: 2485758-49-2
- Formula:C34H35BrF3N5O2
- Molecular Weight:682.57
InChIKey: ZTVCCTBSOVIZBK-JGCGQSQUSA-N
SMILES: NC(N1[C@H](CC(C2=CC=C(C=C2)C(F)(F)F)=N1)C(C3=C4)=CN(CC5=CC=C(C=C5)OCCN6CCCCCC6)C3=CC=C4Br)=O
Biological Activity: (R)-JAK2/STAT3-IN-1 is a GP130 D1 domain inhibitor with anti-tumor activity. (R)-JAK2/STAT3-IN-1 can inhibit the phosphorylation of JAK2 and STAT3. The affinity of (R)-JAK2/STAT3-IN-1 for GP130 protein is 3.8 μM. (R)-JAK2/STAT3-IN-1 effectively inhibits the viability and migration of tumor cells and promotes apoptosis[1].
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(R)-JAK2/STAT3-IN-1 | (R)-JAK2/STAT3-IN-1 is a GP130 D1 domain inhibitor with anti-tumor activity. (R)-JAK2/STAT3-IN-1 can inhibit the phosphorylation of JAK2 and STAT3. The affinity of (R)-JAK2/STAT3-IN-1 for GP130 protein is 3.8 μM. (R)-JAK2/STAT3-IN-1 effectively inhibits the viability and migration of tumor cells and promotes apoptosis. | |||||||||||||||||||||
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References
Keywords
