PDE5/CA-IN-1
PDE5/CA-IN-1 is a dual PDE5 and carbonic anhydrase (CA) inhibitor, with IC50 values of 0.41, 38.4, and 9.1 nM against PDE5, hCA II, and hCA VA, respectively. PDE5/CA-IN-1 inhibits multiple hCA subtypes associated with Alzheimer's disease. As a cytoprotective agent and oxidative stress alleviator, PDE5/CA-IN-1 reduces oxidative stress, and prevents recognition memory and working memory impairments. PDE5/CA-IN-1 is available for the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C24H28N6O6S2
- Molecular Weight:560.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PDE5/CA-IN-1 (Compound 8a) (12.5-100 μM; 24 h) confers protection against Aβ1-42 oligomer-induced cytotoxicity and oxidative stress in differentiated SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 (male, 8-9 weeks old, Alzheimer's disease model via unilateral intracerebroventricular injection of Aβ1-42 peptide)[1]
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Dosage:4 mg/kg
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Administration:i.p.; once daily; 21 consecutive days
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Result:Showed significantly higher discrimination index in novel object recognition test 14 days post-Aβ injection.
Exhibited significantly higher percentage of spontaneous alternations in Y-maze test.
Reduced carbonic anhydrase activity in cortical brain region; no significant change observed in hippocampal region.
Chemical Information
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Molecular Weight 560.65
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Formula C24H28N6O6S2
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SMILES
CCOC1=C(C2=NC(C(CCC)=NN3C)=C3C(N2)=O)C=C(S(NCC4=CC=C(S(=O)(N)=O)C=C4)(=O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE5/CA-IN-1 Related Classifications
HY-181684 Related Classifications
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