2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE) Carbonic Anhydrase
  4. PDE5/CA-IN-1

PDE5/CA-IN-1 is a dual PDE5 and carbonic anhydrase (CA) inhibitor, with IC50 values of 0.41, 38.4, and 9.1 nM against PDE5, hCA II, and hCA VA, respectively. PDE5/CA-IN-1 inhibits multiple hCA subtypes associated with Alzheimer's disease. As a cytoprotective agent and oxidative stress alleviator, PDE5/CA-IN-1 reduces oxidative stress, and prevents recognition memory and working memory impairments. PDE5/CA-IN-1 is available for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

PDE5/CA-IN-1

PDE5/CA-IN-1 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PDE5/CA-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

View All Carbonic Anhydrase Isoform Specific Products:

View All Isoforms
CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PDE5/CA-IN-1 is a dual PDE5 and carbonic anhydrase (CA) inhibitor, with IC50 values of 0.41, 38.4, and 9.1 nM against PDE5, hCA II, and hCA VA, respectively. PDE5/CA-IN-1 inhibits multiple hCA subtypes associated with Alzheimer's disease. As a cytoprotective agent and oxidative stress alleviator, PDE5/CA-IN-1 reduces oxidative stress, and prevents recognition memory and working memory impairments. PDE5/CA-IN-1 is available for the research of Alzheimer's disease[1].

In Vitro

PDE5/CA-IN-1 (Compound 8a) (12.5-100 μM; 24 h) confers protection against Aβ1-42 oligomer-induced cytotoxicity and oxidative stress in differentiated SH-SY5Y cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE5/CA-IN-1 Related Antibodies
In Vivo

PDE5/CA-IN-1 (Compound 8a) (4 mg/kg; i.p.; once daily; 21 consecutive days) prevents Aβ1-42-induced recognition and working memory deficits in mice and significantly reduces cortical CA activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 (male, 8-9 weeks old, Alzheimer's disease model via unilateral intracerebroventricular injection of Aβ1-42 peptide)[1]
Dosage: 4 mg/kg
Administration: i.p.; once daily; 21 consecutive days
Result: Showed significantly higher discrimination index in novel object recognition test 14 days post-Aβ injection.
Exhibited significantly higher percentage of spontaneous alternations in Y-maze test.
Reduced carbonic anhydrase activity in cortical brain region; no significant change observed in hippocampal region.
Molecular Weight

560.65

Formula

C24H28N6O6S2
SMILES

CCOC1=C(C2=NC(C(CCC)=NN3C)=C3C(N2)=O)C=C(S(NCC4=CC=C(S(=O)(N)=O)C=C4)(=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PDE5/CA-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE5/CA-IN-1Phosphodiesterase (PDE)Carbonic AnhydraseCarbonate dehydratasehCA VAAlzheimer's diseaseSH-SY5Y cellsmicecortical CA activityhCA isoformsPDE5human carbonic anhydrasehCA IIAβ1-42 oligomerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PDE5/CA-IN-1
Cat. No.:
HY-181684
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.