MRS2179 tetrasodium hydrate

Cat. No.: HY-101308A Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium hydrate inhibits platelet aggregation.

For research use only. We do not sell to patients.

MRS2179 tetrasodium hydrate Chemical Structure

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5 mg	USD 550	Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
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Description

MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors^[1]^[2]. MRS2179 tetrasodium hydrate inhibits platelet aggregation^[3].

In Vivo

MRS2179 tetrasodium hydrate (50 mg/kg; i.p.) prolongs the bleeding time^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CL57BLr6 mice^[3]
Dosage:	50 mg/kg
Administration:	Injection into the jugular vein of mice
Result:	The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.

Molecular Weight

576.21

Formula

C₁₁H₁₃N₅O₉P₂Na₄.3?H₂O

Appearance

Solid

Color

White to off-white

SMILES

CNC1=C2C(N([C@](C[C@@H]3O[P](O[Na])(O[Na])=O)([H])O[C@@H]3CO[P](O[Na])(O[Na])=O)C=N2)=NC=N1.O.[3.5]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (278 KB) SDS (252 KB)

COA (261 KB) Elemental Analysis Report (119 KB)

Handling Instructions (2659 KB)

References

[1]. Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem. 2000;43(5):829-842. [Content Brief]

[2]. von Kügelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther. 2006;110(3):415-432. [Content Brief]

[3]. Baurand A, Raboisson P, Freund M, et al. Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. Eur J Pharmacol. 2001;412(3):213-221. [Content Brief]