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  2. P2Y Receptor
  3. MRS2179 tetrasodium hydrate

MRS2179 tetrasodium hydrate 

Cat. No.: HY-101308A Purity: >99.0%
Handling Instructions

MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC50=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium hydrate inhibits platelet aggregation.

For research use only. We do not sell to patients.

MRS2179 tetrasodium hydrate Chemical Structure

MRS2179 tetrasodium hydrate Chemical Structure

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Description

MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC50=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors[1][2]. MRS2179 tetrasodium hydrate inhibits platelet aggregation[3].

In Vivo

MRS2179 tetrasodium hydrate (50 mg/kg; i.p.) prolongs the bleeding time[3].

Animal Model: CL57BLr6 mice[3]
Dosage: 50 mg/kg
Administration: Injection into the jugular vein of mice
Result: The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.
Molecular Weight

576.21

Formula

C₁₁H₁₃N₅O₉P₂Na₄.₃½H₂O

SMILES

CNC1=C2C(N([[email protected]](C[[email protected]@H]3O[P](O[Na])(O[Na])=O)([H])O[[email protected]@H]3CO[P](O[Na])(O[Na])=O)C=N2)=NC=N1.O.[3.5]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

MRS2179 tetrasodiumP2Y ReceptorselectivesubtypecompetitiveplateletaggregationInhibitorinhibitorinhibit

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MRS2179 tetrasodium hydrate
Cat. No.:
HY-101308A
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