MRS2179 tetrasodium
Based on 2 publication(s) in Google Scholar
MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC50=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium inhibits platelet aggregation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1454889-37-2
- Fòrmula: C11H13N5Na4O9P2
- Peso molecular:513.16
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-10064
TicagrelorP2Y12 Antagonist -
HY-15284A
Prasugrel hydrochlorideP2Y12 Receptor Antagonist -
HY-108658
MRS2500 tetraammoniumP2Y1 Receptor Antagonist -
HY-108660
PSB-0739P2Y12 Receptor Antagonist -
HY-13104
MRS 2578Apoptosis Inducer -
HY-15799
AZD1283P2Y12 Receptor Antagonist -
HY-W010832
Uridine-5'-diphosphate disodium saltNucleotide -
HY-15283
ClopidogrelAntiplatelet Agent -
HY-108648
2-MeS-ADP trisodiumP2Y Receptor Agonist -
HY-108662
PITP2Y1 Receptor Antagonist -
HY-111557
YM-254890Gαq/11 Selective Inhibitor -
HY-18775
N6-(4-Hydroxybenzyl)adenosineENT1 Inhibitor/A2aR Agonist
Publications Citing Use of MedChemExpress (MCE) MRS2179 tetrasodium
MoreVer todos los productos específicos de isoformas P2Y Receptor
More
Actividad biológica
Descripciòn
IC50 & Target
|
P2Y1 Receptor |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:CL57BLr6 mice[3]
-
Dosage:50 mg/kg
-
Administration:Injection into the jugular vein of mice
-
Result:The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.
Chemical Information
-
No. CAS 1454889-37-2
-
Peso molecular 513.16
-
Fòrmula C11H13N5Na4O9P2
-
SMILES
CNC1=C2C(N([C@](C[C@@H]3O[P](O[Na])(O[Na])=O)([H])O[C@@H]3CO[P](O[Na])(O[Na])=O)C=N2)=NC=N1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Mil Med Res
PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. [Abstract]2024 Jun 27;11(1):41. PMID: 38937853 -
Int J Biol Macromol
Sibanin, a novel black fly-derived Kunitz protease inhibitor, prevents thrombus formation in mice by anticoagulation-antiplatelet duality. [Abstract]2025 Mar:296:139766. PMID: 39800030
Pureza y Documentación
Referencias
[1]. Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem. 2000;43(5):829-842. [Content Brief]
[2]. von Kügelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther. 2006;110(3):415-432. [Content Brief]
[3]. Baurand A, Raboisson P, Freund M, et al. Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. Eur J Pharmacol. 2001;412(3):213-221. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRS2179 tetrasodium Related Classifications
HY-101308 Related Classifications
Powered by Bioz