MRS2179 tetrasodium
Based on 2 publication(s) in Google Scholar
MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC50=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium inhibits platelet aggregation.
For research use only. We do not sell to patients.
- CAS No.: 1454889-37-2
- Formula: C11H13N5Na4O9P2
- Molecular Weight:513.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) MRS2179 tetrasodium
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Biological Activity
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P2Y1 Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CL57BLr6 mice[3]
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Dosage:50 mg/kg
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Administration:Injection into the jugular vein of mice
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Result:The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.
Chemical Information
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CAS No. 1454889-37-2
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Molecular Weight 513.16
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Formula C11H13N5Na4O9P2
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SMILES
CNC1=C2C(N([C@](C[C@@H]3O[P](O[Na])(O[Na])=O)([H])O[C@@H]3CO[P](O[Na])(O[Na])=O)C=N2)=NC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Mil Med Res
PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. [Abstract]2024 Jun 27;11(1):41. PMID: 38937853 -
Int J Biol Macromol
Sibanin, a novel black fly-derived Kunitz protease inhibitor, prevents thrombus formation in mice by anticoagulation-antiplatelet duality. [Abstract]2025 Jan 10:139766. PMID: 39800030
Purity & Documentation
References
[1]. Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem. 2000;43(5):829-842. [Content Brief]
[2]. von Kügelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther. 2006;110(3):415-432. [Content Brief]
[3]. Baurand A, Raboisson P, Freund M, et al. Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. Eur J Pharmacol. 2001;412(3):213-221. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRS2179 tetrasodium Related Classifications
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