1. GPCR/G Protein
  2. P2Y Receptor
  3. MRS2179 tetrasodium

MRS2179 tetrasodium 

Cat. No.: HY-101308
Handling Instructions

MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC50=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium inhibits platelet aggregation.

For research use only. We do not sell to patients.

MRS2179 tetrasodium Chemical Structure

MRS2179 tetrasodium Chemical Structure

CAS No. : 1454889-37-2

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Description

MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC50=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors[1][2]. MRS2179 tetrasodium inhibits platelet aggregation[3].

In Vivo

MRS2179 (50 mg/kg; i.p.) prolongs the bleeding time[3].

Animal Model: CL57BLr6 mice[3]
Dosage: 50 mg/kg
Administration: Injection into the jugular vein of mice
Result: The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.
Molecular Weight

513.16

Formula

C₁₁H₁₃N₅Na₄O₉P₂

CAS No.

1454889-37-2

SMILES

CNC1=C2C(N([[email protected]](C[[email protected]@H]3O[P](O[Na])(O[Na])=O)([H])O[[email protected]@H]3CO[P](O[Na])(O[Na])=O)C=N2)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MRS2179 tetrasodiumP2Y ReceptorselectivesubtypecompetitiveplateletaggregationInhibitorinhibitorinhibit

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MRS2179 tetrasodium
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HY-101308
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