2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Meglitinide

Meglitinide is an ATP-sensitive potassium (KATP) channel inhibitor. Meglitinide exhibits IC50 values of 0.26 μM, 0.53 μM and 1.6 μM against KATP channels containing SUR1, SUR2A and SUR2B, respectively, with a Kd value of 7 μM for both SUR1 and SUR2A, and a Kd value of 8 μM for SUR2B. Meglitinide binds to the SUR1, SUR2A and SUR2B subunits with high affinity to close KATP channels, acting on a binding site shared by all SUR subtypes, and its interaction with SUR1 carrying the S1237Y mutation remains unchanged. Meglitinide is applicable to research related to type 2 diabetes.

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Meglitinide

Meglitinide Chemical Structure

CAS No. : 54870-28-9

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Meglitinide Related Antibodies

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Description

Meglitinide is an ATP-sensitive potassium (KATP) channel inhibitor. Meglitinide exhibits IC50 values of 0.26 μM, 0.53 μM and 1.6 μM against KATP channels containing SUR1, SUR2A and SUR2B, respectively, with a Kd value of 7 μM for both SUR1 and SUR2A, and a Kd value of 8 μM for SUR2B. Meglitinide binds to the SUR1, SUR2A and SUR2B subunits with high affinity to close KATP channels, acting on a binding site shared by all SUR subtypes, and its interaction with SUR1 carrying the S1237Y mutation remains unchanged. Meglitinide is applicable to research related to type 2 diabetes[1].

In Vitro

Meglitinide blocks recombinant Kir6.2/SUR1, Kir6.2/SUR2A, and Kir6.2/SUR2B KATP channels with similar affinities, with IC50 values ranging from 0.26 to 1.6 μmol/l across the channel subtypes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Meglitinide Related Antibodies
Molecular Weight

333.77

Formula

C17H16ClNO4
CAS No.
SMILES

O=C(C1=CC=C(CCNC(C2=CC(Cl)=CC=C2OC)=O)C=C1)O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Meglitinide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meglitinide54870-28-9Potassium ChannelKcsAATP-sensitive potassium (K_ATP) channelpancreatic β-cellSUR2ASUR2Btype 2 diabetesKir6.2/SUR1Kir6.2/SUR2AS1237Y mutationinsulin secretionSUR1Inhibitorinhibitorinhibit

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