54870-28-9
Chemical Structure
Meglitinide
- CAS No.: 54870-28-9
- Formula:C17H16ClNO4
- Molecular Weight:333.77
IUPAC Name: 4-(2-(5-chloro-2-methoxybenzamido)ethyl)benzoic acid
InChIKey: SWLAMJPTOQZTAE-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(CCNC(C2=CC(Cl)=CC=C2OC)=O)C=C1)O
Biological Activity: Meglitinide is an ATP-sensitive potassium (KATP) channel inhibitor. Meglitinide exhibits IC50 values of 0.26 μM, 0.53 μM and 1.6 μM against KATP channels containing SUR1, SUR2A and SUR2B, respectively, with a Kd value of 7 μM for both SUR1 and SUR2A, and a Kd value of 8 μM for SUR2B. Meglitinide binds to the SUR1, SUR2A and SUR2B subunits with high affinity to close KATP channels, acting on a binding site shared by all SUR subtypes, and its interaction with SUR1 carrying the S1237Y mutation remains unchanged. Meglitinide is applicable to research related to type 2 diabetes[1].
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Meglitinide | Meglitinide is an ATP-sensitive potassium (KATP) channel inhibitor. Meglitinide exhibits IC50 values of 0.26 μM, 0.53 μM and 1.6 μM against KATP channels containing SUR1, SUR2A and SUR2B, respectively, with a Kd value of 7 μM for both SUR1 and SUR2A, and a Kd value of 8 μM for SUR2B. Meglitinide binds to the SUR1, SUR2A and SUR2B subunits with high affinity to close KATP channels, acting on a binding site shared by all SUR subtypes, and its interaction with SUR1 carrying the S1237Y mutation remains unchanged. Meglitinide is applicable to research related to type 2 diabetes. | |||||||||||||||||||||
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