CAXII-IN-3
CAXII-IN-3 is an effective carbonic anhydrase (CA XII) inhibitor with a Ki of 53 nM. CAXII-IN-3 exhibits selective inhibition against multiple human CA subtypes with Kis of 5.3 μM, 75 nM, 1.9 μM, > 10 μM against CA I, CA II, CA IV and CA IX. CAXII-IN-3 mainly inhibits CA II and XII, and reduces aqueous humor production. CAXII-IN-3 exhibits β3-AR agonistic activity, can dilate retinal blood vessels, and improve optic nerve perfusion. CAXII-IN-3 can be used in the research of ocular disorders such as glaucoma.
For research use only. We do not sell to patients.
- Formula: C26H25N3O3S
- Molecular Weight:459.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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hCA XII 53 nM (Ki) |
hCA II 75 nM (Ki) |
hCA I 5.3 μM (Ki) |
hCA IX > 10 μM (Ki) |
Beta-1 adrenergic receptor |
Beta-2 adrenergic receptor |
Beta-3 adrenergic receptor |
CAXII-IN-3 (Compound 14) (0.1 pM-10 μM) increases cAMP production in HEK293T cells stably expressing β1, β2, and β3-adrenergic receptor subtypes with pEC50 values of 5.00, 5.29 and 4.98[1].
CAXII-IN-3 (1 nM-0.1 μM, 0-50 min) induces complete vasodilation in isolated porcine retinal artery rings with an EC50 of 11 μM[1].
CAXII-IN-3 (4 μM, 2 h) exhibits substantial melanosomal accumulation porcine retinal pigment epithelium (RPE) comparable to Propranolol (HY-B0573B)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Instantaneous high intraocular pressure model established in New Zealand White (NZW) rabbits[1]
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Dosage:30 μL of 1% solution
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Administration:Eye drip, single dose
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Result:Produced the greatest and most sustained effect.
Chemical Information
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Molecular Weight 459.56
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Formula C26H25N3O3S
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SMILES
NC1=CC=C(C=C1)CCNC[C@@H](C2=CC=CC=C2)OC(NC3=CC(C=C4)=C(C=C3)OC4=O)=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAXII-IN-3 Related Classifications
HY-178030 Related Classifications
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