1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB-215505

SB-215505 

Cat. No.: HY-18596
Handling Instructions

SB-215505 is a potent and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively. SB-215505 increases wakefulness and motor activity in rats.

For research use only. We do not sell to patients.

SB-215505 Chemical Structure

SB-215505 Chemical Structure

CAS No. : 162100-15-4

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SB-215505 is a potent and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively[1]. SB-215505 increases wakefulness and motor activity in rats[2].

IC50 & Target[1]

5-HT2B Receptor

8.3 (pKi)

5-HT2A Receptor

6.77 (pKi)

5-HT2C Receptor

7.66 (pKi)

In Vitro

SB-215505 is 30 fold selective for the 5-HT2B over the 5-HT2A receptor, and only marginally selective over the 5-HT2C receptor[1].

In Vivo

SB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2[2].

Animal Model: Male Sprague-Dawley rats weighing 230-260 g[2]
Dosage: 0.1, 0.3 and 1.0 mg/kg
Administration: IP; two doses (4 days between two doses)
Result: Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2.
Molecular Weight

337.80

Formula

C₁₉H₁₆ClN₃O

CAS No.

162100-15-4

SMILES

O=C(N1CCC2=C1C=C(Cl)C(C)=C2)NC3=C4C=CC=NC4=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SB-215505SB215505SB 2155055-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorwakefulnessmotoractivityintermediatestageofsleepISparadoxicalPSSWS-2Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SB-215505
Cat. No.:
HY-18596
Quantity:
MCE Japan Authorized Agent: