TSC22D1 Antibody (YA8558)

Cat. No.: HY-P88874: Data Sheet User Guide for Antibodies
FAQs
Technical Support

TSC22D1 Antibody (YA8558) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TSC22D1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

TSC22D1 Antibody (YA8558) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TSC22D1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 15.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q15714

Immunogen

Full length human recombinant protein of human TSC22D1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201)|May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells|Positively regulates cell death in response to TGFB3 during mammary gland involution

Subcellular Localization：Cytoplasm,Nucleus,Cell membrane,Cytoplasm,Nucleus,Mitochondrion,Cytoplasm,Nucleus,Mitochondrion,Cytoplasm,Nucleus

Expression：
Tissue_Specificity: Ubiquitously expressed in adult tissues (PubMed:26752201, PubMed:8651929). Expressed in the postmitotic epithelial compartment at the top of intestinal mucosal villi (PubMed:12468551)
Induction: Induced by cytokines including TGFB1 in aortic endothelial cells

Isoforms & Post-Translational Modification：Q15714 has 5 isomers: Q15714-1: 109677 Da (predicted); Q15714-2: 15680 Da (predicted); Q15714-3: 59863 Da (predicted); Q15714-4: 58859 Da (predicted); Q15714-5: 9369 Da (predicted).

Subunit：Forms homodimers (PubMed:10488076)

Synonyms

Ptg-2; TGFB1I4; TSC22

Documentation

User Guide for Antibodies (1077 KB)