TSC22D1 Antibody (YA8558)
(Synonyms: Ptg-2; TGFB1I4; TSC22)TSC22D1 Antibody (YA8558) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TSC22D1.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100 |
Product Details
TSC22D1 Antibody (YA8558) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TSC22D1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 15.5 kDa
Full length human recombinant protein of human TSC22D1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TSC22D1 transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter. Acts to promote CASP3-mediated apoptosis. Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1. Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4. Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter. Plays a role in the repression of hematopoietic precursor cell growth. Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade |May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells|Positively regulates cell death in response to TGFB3 during mammary gland involution[1][2][3][4][5][6].
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Subcellular Localization
Cytoplasm,Nucleus,Cell membrane,Cytoplasm,Nucleus,Mitochondrion,Cytoplasm,Nucleus,Mitochondrion,Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Ubiquitously expressed in adult tissues (PubMed:26752201, PubMed:8651929). Expressed in the postmitotic epithelial compartment at the top of intestinal mucosal villi (PubMed:12468551)
Induction: Induced by cytokines including TGFB1 in aortic endothelial cells -
Isoforms & Post-Translational Modification
Q15714 has 5 isomers: Q15714-1: 109677 Da (predicted); Q15714-2: 15680 Da (predicted); Q15714-3: 59863 Da (predicted); Q15714-4: 58859 Da (predicted); Q15714-5: 9369 Da (predicted).
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Subunit
Forms homodimers (PubMed:10488076)
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SwissProt ID
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Synonyms
Ptg-2; TGFB1I4; TSC22
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