Ropeginterferon alfa-2b
Based on 1 Customer Validation
Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms.
For research use only. We do not sell to patients.
- Purity: 95%
- CAS No.: 1335098-50-4
- Molecular Weight:60 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ropeginterferon alfa-2b (5 μg/mL; 72 h) suppresses growth, induces apoptosis and arrests cell cycle at G1 phase in BA-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BA-1 cells
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Concentration:5 μg/mL
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Incubation Time:72 h
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Result:Suppressed BA-1 growth.
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Cell Line:BA-1 cells
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Concentration:5 μg/mL
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Incubation Time:24, 48 and 72 h
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Result:Showed an increase in early- and late-apoptotic cells in a time-dependent manner. Promoted a time-dependent increase in caspase-3 expression.
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Cell Line:BA-1 cells
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Concentration:5 μg/mL
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Incubation Time:24, 48 and 72 h
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Result:Induced an increase in G1 phase.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (8-12 weeks) with BA-1 cells[1]
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Dosage:5 μg/mouse
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Administration:Subcutaneous injection, on day 5 after tumor inoculation
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Result:Led to long-term remission in four of eight (50%) mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Conjugated with pegol
The product can be reconstituted/diluted with sterile PBS or saline.
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IFNA2 (interferon alpha 2)*b (R46,H57)24-188 R46
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 1335098-50-4
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Appearance Liquid
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Molecular Weight 60 kDa
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Color Colorless to light yellow
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SMILES
[Ropeginterferon alfa-2b]
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Synonyms
Ropeginterferon alfa-2b-njft; PEG-proline-interferon alpha-2b
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ropeginterferon alfa-2b Related Classifications
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