1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. ABT-724

ABT-724 

Cat. No.: HY-14330
Handling Instructions

ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.

For research use only. We do not sell to patients.

ABT-724 Chemical Structure

ABT-724 Chemical Structure

CAS No. : 70006-24-5

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Description

ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].

IC50 & Target

EC50: 12.4 nM (Human dopamine D4 receptor), 14.3 nM (Rat dopamine D4 receptor) and 23.2 nM (Ferret dopamine D4 receptor)[1]

In Vitro

ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations[1].

In Vivo

ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats[1].

Animal Model: Male adult Wistar rats (~300 g)[1]
Dosage: 8.8 μg/kg
Administration: Subcutaneous injection; daily; for 5 days
Result: Dose-dependently facilitated penile erection.
Molecular Weight

293.37

Formula

C₁₇H₁₉N₅

CAS No.

70006-24-5

SMILES

C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ABT-724ABT724ABT 724Dopamine ReceptorDopamineD4-receptorpenileerectionpotentiation,side-effectInhibitorinhibitorinhibit

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