ABT-724

Cat. No.: HY-14330 Purity: 98.04%: Data Sheet
COA

SDS
Handling Instructions
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ABT-724, a chemical probe, is a potent and highly selective dopamine D₄ receptor agonist with an EC₅₀ of 12.4 nM for human dopamine D₄ receptor. ABT-724 is a potent partial agonist at the rat D₄ (EC₅₀ of 14.3 nM) and the ferret D₄ receptor (EC₅₀ of 23.2 nM). ABT-724 has no effect on dopamine D₁, D₂, D₃, or D₅ receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.

For research use only. We do not sell to patients.

ABT-724 Chemical Structure

CAS No. : 70006-24-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of ABT-724:

ABT-724 trihydrochloride In-stock

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

D₄ Receptor

D₅ Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	12.4 nM Compound: 1 (ABT-724)	In vitro EC50 tested on HEK293 cells co-transfected with human Dopamine receptor D4.4 using FLIPR assay In vitro EC50 tested on HEK293 cells co-transfected with human Dopamine receptor D4.4 using FLIPR assay	[PMID: 15239663]
HEK293	EC₅₀	12.4 nM Compound: 1a, ABT-724	Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR	[PMID: 17149874]
HEK293	EC₅₀	12.4 nM Compound: 3a	D4 efficacy was measured using recombinant human Dopamine receptor D4 expressed in HEK293 cells D4 efficacy was measured using recombinant human Dopamine receptor D4 expressed in HEK293 cells	[PMID: 15084133]
HEK293	EC₅₀	13.7 nM Compound: 1a, ABT-724	Agonist activity at rat D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR Agonist activity at rat D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR	[PMID: 17149874]
HEK293	EC₅₀	14.3 nM Compound: 1 (ABT-724)	In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D4 using FLIPR assay In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D4 using FLIPR assay	[PMID: 15239663]
HEK293	EC₅₀	23.2 nM Compound: 1 (ABT-724)	In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D4 using FLIPR assay In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D4 using FLIPR assay	[PMID: 15239663]

In Vitro

ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D₂, D₃, or D₅ receptors up to a 10 μM concentration. A weak affinity to 5-HT_1A receptors (K_i = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male adult Wistar rats (~300 g)^[1]
Dosage:	8.8 μg/kg
Administration:	Subcutaneous injection; daily; for 5 days
Result:	Dose-dependently facilitated penile erection.

Molecular Weight

293.37

Formula

C₁₇H₁₉N₅

CAS No.

70006-24-5

Appearance

Solid

Color

Off-white to light yellow

SMILES

C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 4.17 mg/mL (14.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4087 mL	17.0433 mL	34.0866 mL
5 mM	0.6817 mL	3.4087 mL	6.8173 mL
10 mM	0.3409 mL	1.7043 mL	3.4087 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.04%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (252 KB) HNMR (171 KB) RP-HPLC (261 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Brioni JD, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4087 mL	17.0433 mL	34.0866 mL	85.2166 mL
	5 mM	0.6817 mL	3.4087 mL	6.8173 mL	17.0433 mL
	10 mM	0.3409 mL	1.7043 mL	3.4087 mL	8.5217 mL

ABT-724 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-72470006-24-5ABT724ABT 724Dopamine ReceptorDopamineD4-receptorpenileerectionpotentiation,side-effectInhibitorinhibitorinhibit

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