70006-24-5
Chemical Structure
ABT-724
- CAS. Nr.: 70006-24-5
- Formula:C17H19N5
- Molecular Weight:293.37
IUPAC Name: 2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole
InChIKey: FRPJGTNLZNXQEX-UHFFFAOYSA-N
SMILES: C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1
Biological Activity: ABT-724, a chemical probe, is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].
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ABT-724 | 98.04% | ABT-724, a chemical probe, is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile. | ||||||||||||||||||||
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