1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. ABT-724 trihydrochloride

ABT-724 trihydrochloride 

Cat. No.: HY-103409 Purity: 99.12%
Handling Instructions

ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.

For research use only. We do not sell to patients.

ABT-724 trihydrochloride Chemical Structure

ABT-724 trihydrochloride Chemical Structure

CAS No. : 587870-77-7

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10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
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25 mg USD 320 In-stock
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50 mg USD 512 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].

IC50 & Target

EC50: 12.4 nM (Human dopamine D4 receptor), 14.3 nM (Rat dopamine D4 receptor) and 23.2 nM (Ferret dopamine D4 receptor)[1]

In Vitro

ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult Wistar rats (~300 g)[1]
Dosage: 8.8 μg/kg
Administration: Subcutaneous injection; daily; for 5 days
Result: Dose-dependently facilitated penile erection.
Molecular Weight

402.75

Formula

C17H22Cl3N5

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (248.29 mM)

DMSO : 20 mg/mL (49.66 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4829 mL 12.4146 mL 24.8293 mL
5 mM 0.4966 mL 2.4829 mL 4.9659 mL
10 mM 0.2483 mL 1.2415 mL 2.4829 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.12%

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Product Name:
ABT-724 trihydrochloride
Cat. No.:
HY-103409
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