country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-14541A

Copy Link Print Information

Olanzapine hydrochloride

(Synonyms: LY170053 hydrochloride)

14 Cited Publications

Kundenbewertung

Based on 14 publication(s) in Google Scholar

Olanzapine hydrochloride is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine hydrochloride is an atypical antipsychotic.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 783334-36-1
Formel: C₁₇H₂₁ClN₄S
Molecular Weight:348.89

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Olanzapine hydrochloride Chemical Structure

CAS. Nr.: 783334-36-1

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Publications (14)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

5-HT_2A Receptor

5-HT₆ Receptor

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

Alle mAChR Isoform-spezifische Produkte anzeigen :

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 783334-36-1
Molecular Weight 348.89
Formel C₁₇H₂₁ClN₄S
SMILES

CN(CC1)CCN1C2=NC3=C(NC4=C2C=C(C)S4)C=CC=C3.Cl
Synonyms

LY170053 hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (14)

All ELISAWBHistological Imaging/StainingRT-PCRCell Proliferation/Viability Assay

Sort by:

Journal Impact Factor

Nat Commun

Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells. [Abstract]

2022 Nov 10;13(1):6796. PMID: 36357388

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 10;13(1):6796. [Abstract]

Relative CHOP-Luc activities of individual tested compounds (Olanzapine) at 20 µM in the presence of Tm/Tg (1 µM) relative to DMSO, 24 hours after exposure.
Acta Pharmacol Sin

Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats. [Abstract]

2021 Aug;42(8):1267-1279. PMID: 33976388

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279. [Abstract]

Olanzapine (Ola: 1.0 mg/kg). Serum insulin-metabolizing hormone levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit.

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279. [Abstract]

Olanzapine (Ola: 1.0 mg/kg). The expression level of GLP-1 protein in small intestinal tissue was detected by Western blot analysis.

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279. [Abstract]

Olanzapine (Ola: 1.0 mg/kg). GLP-1 immunohistochemical staining was performed on paraffin sections of the small intestine.

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279. [Abstract]

Olanzapine (Ola: 1.0 mg/kg). The mRNA expression level in liver tissue was detected using real-time quantitative PCR.
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Front Pharmacol

Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine. [Abstract]

2022 Aug 12:13:935362. PMID: 36034782
ACS Omega

Involvement of Integrated Stress Response in Drug-Induced Secondary Dystonia. [Abstract]

2025 Oct 17;10(42):50208-50217. PMID: 41179162
Brain Pathol

DCC in the cerebral cortex is required for cognitive functions in mouse. [Abstract]

2025 May;35(3):e13306. PMID: 39293934
Drug Dev Res

SEP-363856 exerts neuroprotection through the PI3K/AKT/GSK-3β signaling pathway in a dual-hit neurodevelopmental model of schizophrenia-like mice. [Abstract]

2024 Jun;85(4):e22225. PMID: 38879781
Toxicol Appl Pharmacol

Paeoniflorin attenuates hyperprolactinemia by targeting the pituitary mPRα-mediated, dopamine receptor-independent signaling in vivo and in vitro. [Abstract]

2025 Dec:505:117551. PMID: 40939721
Patent

US20250295610A1.
University of South Carolina

2025.
Research Square Print

2022 Aug.
medRxiv

2021 Mar 1.
bioRxiv

2021 Mar 02.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. APPROVED AGREED-UPON LABELING.

[2]. Olanzapine for Injection, powder, for solution for intramuscular use.

[3]. Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78. [Content Brief]

[4]. Karpel-Massler G, et al. Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect. J Neurooncol. 2015 Mar;122(1):21-33. [Content Brief]

[5]. Coccurello R, et al. Chronic administration of olanzapine induces metabolic and food intake alterations: a mousemodel of the atypical antipsychotic-associated adverse effects. Psychopharmacology (Berl). 2006 Jul;186(4):561-71. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Olanzapine hydrochloride

14 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Publications (14)
Reinheit & Dokumentation
Verweise

1/16
1/16

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 10;13(1):6796. [Abstract]

Customer Validation
Relative CHOP-Luc activities of individual tested compounds (Olanzapine) at 20 µM in the presence of Tm/Tg (1 µM) relative to DMSO, 24 hours after exposure.
1/16

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279. [Abstract]

Customer Validation
Olanzapine (Ola: 1.0 mg/kg). Serum insulin-metabolizing hormone levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit.
1/16

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279. [Abstract]

Customer Validation
Olanzapine (Ola: 1.0 mg/kg). The expression level of GLP-1 protein in small intestinal tissue was detected by Western blot analysis.
1/16

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279. [Abstract]

Customer Validation
Olanzapine (Ola: 1.0 mg/kg). GLP-1 immunohistochemical staining was performed on paraffin sections of the small intestine.
1/16

Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279. [Abstract]

Customer Validation
Olanzapine (Ola: 1.0 mg/kg). The mRNA expression level in liver tissue was detected using real-time quantitative PCR.

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Olanzapine hydrochloride

Publications Citing Use of MedChemExpress (MCE) Olanzapine hydrochloride

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen

Alle mAChR Isoform-spezifische Produkte anzeigen

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (14)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Olanzapine hydrochloride Related Classifications

HY-14541A Related Classifications