2. GPCR/G Protein Neuronal Signaling Autophagy Apoptosis
  3. 5-HT Receptor Dopamine Receptor mAChR Adrenergic Receptor Autophagy Mitophagy Apoptosis
  4. Olanzapine hydrochloride

Olanzapine hydrochloride  (Synonyms: LY170053 hydrochloride)

Cat. No.: HY-14541A
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Olanzapine hydrochloride is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine hydrochloride is an atypical antipsychotic.

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CAS No. : 783334-36-1

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Top Publications Citing Use of Products

    Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 10;13(1):6796.  [Abstract]

    Relative CHOP-Luc activities of individual tested compounds (Olanzapine) at 20 µM in the presence of Tm/Tg (1 µM) relative to DMSO, 24 hours after exposure.

    Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279.  [Abstract]

    Olanzapine (Ola: 1.0 mg/kg). Serum insulin-metabolizing hormone levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit.

    Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279.  [Abstract]

    Olanzapine (Ola: 1.0 mg/kg). The expression level of GLP-1 protein in small intestinal tissue was detected by Western blot analysis.

    Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279.  [Abstract]

    Olanzapine (Ola: 1.0 mg/kg). GLP-1 immunohistochemical staining was performed on paraffin sections of the small intestine.

    Olanzapine hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Aug;42(8):1267-1279.  [Abstract]

    Olanzapine (Ola: 1.0 mg/kg). The mRNA expression level in liver tissue was detected using real-time quantitative PCR.

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    Description

    Olanzapine hydrochloride is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine hydrochloride is an atypical antipsychotic[1][2].

    IC50 & Target

    5-HT2A Receptor

     

    5-HT6 Receptor

     

    Molecular Weight

    348.89

    Formula

    C17H21ClN4S
    CAS No.
    SMILES

    CN(CC1)CCN1C2=NC3=C(NC4=C2C=C(C)S4)C=CC=C3.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Olanzapine hydrochloride Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Olanzapine783334-36-1LY170053LY 170053LY-1700535-HT ReceptorDopamine ReceptormAChRAdrenergic ReceptorAutophagyMitophagyApoptosisSerotonin Receptor5-hydroxytryptamine ReceptorMuscarinic acetylcholine receptorBeta ReceptorMitochondrial Autophagy5-HT2D1D2antipsychoticanticholinergicmitochondrialdamageSH-SY5YneuronalcellInhibitorinhibitorinhibit

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