TBC1D1 Antibody (YA7013)
(Synonyms: KIAA1108 antibody; TBC 1 antibody; TBC antibody; TBC1 (tre 2/USP6, BUB2, cdc16) domain family, member 1 antibody; TBC1 antibody; TBC1 domain family member 1 antibody; Tbc1d1 antibody; TBCD1_HUMAN antibody)TBC1D1 Antibody (YA7013) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TBC1D1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:10000-1:50000 | 1:200 | 1-2μg/sample |
Product Details
TBC1D1 Antibody (YA7013) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TBC1D1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 150 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 133 kDa
Recombinant protein within human TBC1D1 aa 1-430.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TBC1D1 may act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
Q86TI0 has two isomers: Q86TI0-1: 133084 Da (predicted); Q86TI0-2: 131378 Da (predicted).
Insulin-stimulated phosphorylation by AKT family kinases stimulates SLC2A4/GLUT4 translocation -
Subunit
Interacts with APPL2 (via BAR domain); interaction is dependent of TBC1D1 phosphorylation at Ser-235; interaction diminishes the phosphorylation of TBC1D1 at Thr-596, resulting in inhibition of SLC2A4/GLUT4 translocation and glucose uptake
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SwissProt ID
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Synonyms
KIAA1108 antibody; TBC 1 antibody; TBC antibody; TBC1 (tre 2/USP6, BUB2, cdc16) domain family, member 1 antibody; TBC1 antibody; TBC1 domain family member 1 antibody; Tbc1d1 antibody; TBCD1_HUMAN antibody
Documentation
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