1. Cell Cycle/DNA Damage
  2. CDK
  3. NSC 625987

NSC 625987 

Cat. No.: HY-103380
Handling Instructions

NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2.

For research use only. We do not sell to patients.

NSC 625987 Chemical Structure

NSC 625987 Chemical Structure

CAS No. : 141992-47-4

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Description

NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].

IC50 & Target[1]

CDK4/D1

0.2 μM (IC50)

In Vitro

NSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

271.33

Formula

C₁₅H₁₃NO₂S

CAS No.
SMILES

S=C1C2=C(C=CC=C2)NC3=C(OC)C=CC(OC)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NSC 625987NSC625987NSC-625987CDKCyclin dependent kinaseCDK4:cyclin D1anti-proliferationInhibitorinhibitorinhibit

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NSC 625987
Cat. No.:
HY-103380
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