1. GPCR/G Protein
  2. LPL Receptor
  3. Radioprotectin-1

Radioprotectin-1 

Cat. No.: HY-114380 Purity: 99.44%
Handling Instructions

Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA2), with an EC50 value of 25 nM for murine LPA2 subtype.

For research use only. We do not sell to patients.

Radioprotectin-1 Chemical Structure

Radioprotectin-1 Chemical Structure

CAS No. : 1622006-09-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
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Description

Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA2), with an EC50 value of 25 nM for murine LPA2 subtype[1].

IC50 & Target

EC50: 25 nM (murine LPA2 subtype)[1]

In Vitro

Radioprotectin-1 is a potent agonist of LPA2 with an EC50 of 5 pM and functions as a full agonist at the human ortholog of LPA2[1].
Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA2 either endogenously or after transfection[1].

Cell Viability Assay[1]

Cell Line: MEF cells , IEC-6 cells
Concentration: 0 μM, 0.1 μM, 0.3 μM, 1.0 μM,3 μM
Incubation Time: 15 minutes
Result: Protected cells from apoptosis by γ-irradiation- and the radiomimetic chemotherapeutic Adiamycin.
In Vivo

Radioprotectin-1 is a high-potency specific agonist of the murine LPA2 GPCR [1].
Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) [1].
Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA2 GPCR in Lgr5+stem cells[1].

Animal Model: 8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI) [1]
Dosage: 0.1 mg/kg, 0.3 mg/kg
Administration: Subcutaneous injection; every 12 hours; for 3 days
Result: Decreased mortality of C57BL/6 mice in models of the HE-ARS and the GI-ARS.
Molecular Weight

486.92

Formula

C₂₃H₁₉ClN₂O₆S

CAS No.

1622006-09-0

SMILES

O=C(O)C1=CC(Cl)=CC=C1S(=O)(NCCCCN(C(C2=CC=CC3=CC=CC4=C23)=O)C4=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (256.72 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0537 mL 10.2686 mL 20.5373 mL
5 mM 0.4107 mL 2.0537 mL 4.1075 mL
10 mM 0.2054 mL 1.0269 mL 2.0537 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.27 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.27 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.27 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Radioprotectin-1
Cat. No.:
HY-114380
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