Ro4491533
Ro4491533 is a selective, negative allosteric mGluR2/3 receptor modulator that is equally effective on both subtypes. Ro4491533 can completely block glutamate-induced calcium mobilization and glutamate-induced [35S]GTPγS binding accumulation. Ro4491533 has good pharmacokinetic properties in mice and rats, high oral bioavailability, and can pass through the blood-brain barrier. Ro4491533 can also reverse the motor inhibition effect of LY379268 in mice and show antidepressant activity in the forced swim test and tail suspension test.
For research use only. We do not sell to patients.
- CAS No.: 579482-31-8
- Formula: C24H20F3N3O
- Molecular Weight:423.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
<0.01 μM
Compound: 7am
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Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current
Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current
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[PMID: 20971004] |
| CHO | IC50 |
<0.01 μM
Compound: 7am
|
Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current
Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current
|
[PMID: 20971004] |
| CHO | IC50 |
0.003 μM
Compound: 7am
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Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP production
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP production
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[PMID: 20971004] |
| CHO | IC50 |
0.014 μM
Compound: 7am
|
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current
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[PMID: 20971004] |
Chemical Information
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CAS No. 579482-31-8
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Molecular Weight 423.43
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Formula C24H20F3N3O
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SMILES
O=C1NC2=CC(C(F)(F)F)=C(C=C2N=C(C1)C3=CC=CC(C4=CC(C)=NC(C)=C4)=C3)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ro4491533 Related Classifications
HY-118285 Related Classifications
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