UTA1inh-D1
UTA1inh-D1 is a selective UT-A1 and UT-B urea transporter inhibitor with IC50 values of 3.8 μM and 15 μM, respectively. UTA1inh-D1 is promising for research of refractory edema, such as congestive heart failure and cirrhosis.
For research use only. We do not sell to patients.
- CAS No.: 892745-28-7
- Formula: C18H19N5O2S2
- Molecular Weight:401.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.35 μM
Compound: 2{8,2}
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Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production
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[PMID: 20541425] |
| HEK293 | IC50 |
28.3 nM
Compound: 2{8,2}
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Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay
Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay
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[PMID: 20541425] |
Chemical Information
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CAS No. 892745-28-7
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Molecular Weight 401.50
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Formula C18H19N5O2S2
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SMILES
O=S(=O)(C=1N=NN2C1N=C(NC(C)C)C=3SC=CC32)C4=CC(=CC=C4C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UTA1inh-D1 Related Classifications
HY-116718 Related Classifications
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