1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. LCAHA

LCAHA (Synonyms: LCA hydroxyamide)

Cat. No.: HY-120458
Handling Instructions

LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a.

For research use only. We do not sell to patients.

LCAHA Chemical Structure

LCAHA Chemical Structure

CAS No. : 117094-40-3

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Description

LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a[1].

In Vitro

LCAHA inhibits HCT116wt and HCT116 p53-/- colon cancer cells viability with GI50s of 0.87±0.09 and 0.96±0.29μM, respectively, and the LD50s of 27.8±3.9 and 26.5±0.1μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCT116wt and HCT116 p53-/- colon cancer cells
Concentration: 0.01, 0.1, 1, 10, and 100 μM
Incubation Time: 6 days
Result: The GI50s are 0.87±0.09 and 0.96±0.29 μM for HCT116wt and HCT116 p53-/- colon cancer cells, respectively.
Molecular Weight

391.59

Formula

C₂₄H₄₁NO₃

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LCAHALCA hydroxyamideDeubiquitinaseDUBscyclin D1p53HCT116coloncancercellsInhibitorinhibitorinhibit

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