117094-40-3
Chemical Structure
LCAHA
Synonym(s): LCA hydroxyamide
- CAS No.: 117094-40-3
- Formula:C24H41NO3
- Molecular Weight:391.59
IUPAC Name: (R)-N-hydroxy-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamide
InChIKey: WZXAGWREMCSWMF-HVATVPOCSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NO)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
Biological Activity: LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LCAHA | 99.91% | LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a. | ||||||||||||||||||||
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Keywords
