1. GPCR/G Protein
    Neuronal Signaling
  2. Somatostatin Receptor
  3. SSTR5 antagonist 2

SSTR5 antagonist 2 

Cat. No.: HY-114191
Handling Instructions

SSTR5 antagonist 2 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential to treat type 2 diabetes mellitus (T2DM).

For research use only. We do not sell to patients.

SSTR5 antagonist 2 Chemical Structure

SSTR5 antagonist 2 Chemical Structure

CAS No. : 1254730-81-8

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Description

SSTR5 antagonist 2 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential to treat type 2 diabetes mellitus (T2DM)[1].

IC50 & Target

SSTR5[1].

In Vivo

SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1].
SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1].

Animal Model: Rodent diabetic model without risk of hypoglycemia[1].
Dosage: 10 mg/kg.
Administration: Orally.
Result: Increased both total and active circulating incretin hormone GLP1 levels.
Molecular Weight

546.63

Formula

C₃₂H₃₅FN₂O₅

CAS No.

1254730-81-8

SMILES

FC(C=C1)=CC=C1C2=C(OCC)C=C(CN3CCC4(CN(C5=CC=C(C(O)=O)C=C5)C(C4)=O)CC3)C=C2OCC

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Please store the product under the recommended conditions in the Certificate of Analysis.

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SSTR5 antagonist 2
Cat. No.:
HY-114191
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