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Art. -Nr.: HY-14312

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A85380

A 85380 is a novel, high affinity neuronal nicotinic acetylcholine receptor (nAChR) agonist. A 85380 exhibits selectivity for the α4β2 nAChR subtypes. A 85380 has a broad-spectrum analgesic profile.

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CAS. Nr.: 161416-98-4
Formel: C₉H₁₂N₂O
Molecular Weight:164.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

A85380 Chemical Structure

CAS. Nr.: 161416-98-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
IMR-32	EC₅₀	0.7 μM Compound: 2, A-85380	Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype	[PMID: 9484491]
IMR-32	EC₅₀	0.7 μM Compound: 4a	Ability to stimulate Rb+ efflux from human IMR-32 cell preparations containing human alpha3-betaX receptors Ability to stimulate Rb+ efflux from human IMR-32 cell preparations containing human alpha3-betaX receptors	[PMID: 8632405]
K177 cell line	EC₅₀	0.68 μM Compound: 4a	Ability to stimulate Rb+ efflux from human K177 cell preparations containing human alpha4-beta2 receptors Ability to stimulate Rb+ efflux from human K177 cell preparations containing human alpha4-beta2 receptors	[PMID: 8632405]
K177 cell line	EC₅₀	0.7 μM Compound: 2, A-85380	Compound was evaluated for functional activation to [86Rb+] efflux from human K177 cells expressing recombinant alpha4-beta2 receptors. Compound was evaluated for functional activation to [86Rb+] efflux from human K177 cells expressing recombinant alpha4-beta2 receptors.	[PMID: 9484491]
Oocyte	EC₅₀	8.9 μM Compound: 2, A-85380	Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes. Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.	[PMID: 9484491]

Chemical Information

CAS. Nr. 161416-98-4
Molecular Weight 164.20
Formel C₉H₁₂N₂O
SMILES

C1(OC[C@@H]2CCN2)=CN=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sullivan J P, et al. A-85380 [3-(2 (S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand[J]. Neuropharmacology, 1996, 35(6): 725-734.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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