A85380
A 85380 is a novel, high affinity neuronal nicotinic acetylcholine receptor (nAChR) agonist. A 85380 exhibits selectivity for the α4β2 nAChR subtypes. A 85380 has a broad-spectrum analgesic profile.
For research use only. We do not sell to patients.
- CAS No.: 161416-98-4
- Formula: C9H12N2O
- Molecular Weight:164.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IMR-32 | EC50 |
0.7 μM
Compound: 2, A-85380
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Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype
Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype
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[PMID: 9484491] |
| IMR-32 | EC50 |
0.7 μM
Compound: 4a
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Ability to stimulate Rb+ efflux from human IMR-32 cell preparations containing human alpha3-betaX receptors
Ability to stimulate Rb+ efflux from human IMR-32 cell preparations containing human alpha3-betaX receptors
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[PMID: 8632405] |
| K177 cell line | EC50 |
0.68 μM
Compound: 4a
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Ability to stimulate Rb+ efflux from human K177 cell preparations containing human alpha4-beta2 receptors
Ability to stimulate Rb+ efflux from human K177 cell preparations containing human alpha4-beta2 receptors
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[PMID: 8632405] |
| K177 cell line | EC50 |
0.7 μM
Compound: 2, A-85380
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Compound was evaluated for functional activation to [86Rb+] efflux from human K177 cells expressing recombinant alpha4-beta2 receptors.
Compound was evaluated for functional activation to [86Rb+] efflux from human K177 cells expressing recombinant alpha4-beta2 receptors.
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[PMID: 9484491] |
| Oocyte | EC50 |
8.9 μM
Compound: 2, A-85380
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Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.
Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.
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[PMID: 9484491] |
Chemical Information
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CAS No. 161416-98-4
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Molecular Weight 164.20
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Formula C9H12N2O
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SMILES
C1(OC[C@@H]2CCN2)=CN=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
A85380 Related Classifications
HY-14312 Related Classifications
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