Nav1.8-IN-16
Nav1.8-IN-16 (Compound (R)-40) is an orally active and selective hNaV 1.8 inhibitor (IC50: 5.9 nM). Nav1.8-IN-16 exerts analgesic effects by blocking NaV1.8 channels without significantly affecting other NaV subtypes or hERG channels. Nav1.8-IN-16 exhibits dose-dependent analgesic effects in postoperative pain and inflammatory pain models and can be used in pain-related research.
For research use only. We do not sell to patients.
- Formula: C24H16ClF5N2O3
- Molecular Weight:510.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Nav1.8 5.9 nM (IC50) |
Chemical Information
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Molecular Weight 510.84
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Formula C24H16ClF5N2O3
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SMILES
O=C(NC1=CC=C(F)C(C(N)=O)=C1)C2=CC(Cl)=C(C(F)(F)F)C=C2[C@H]3CCOC4=C3C=CC=C4F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)