2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. VU6005806

VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders.

For research use only. We do not sell to patients.

VU6005806 Chemical Structure

VU6005806 Chemical Structure

CAS No. : 2180914-37-6

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VU6005806 Related Antibodies

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Description

VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1].

IC50 & Target

IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]
Molecular Weight

439.41

Formula

C17H16F3N7O2S
CAS No.
SMILES

NC1=C(C(NC2CN(C3=NC=C(C(F)(F)F)C=N3)C2)=O)SC4=NN=C(OC)C(C)=C41
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU6005806 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU60058062180914-37-6AZN-00016130VU 6005806VU-6005806AZN00016130AZN 00016130mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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