1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. BODIPY FL prazosin

BODIPY FL prazosin 

Cat. No.: HY-D1606
Handling Instructions

BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes.

For research use only. We do not sell to patients.

BODIPY FL prazosin Chemical Structure

BODIPY FL prazosin Chemical Structure

CAS No. : 175799-93-6

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Description

BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes[1][2][3].

IC50 & Target[1]

α1A-adrenergic receptor

14.5 nM (Ki)

α1B-adrenergic receptor

43.3 nM (Ki)

In Vitro

BODIPY FL prazosin (10 nM; 30 min at room temperature in 100 μl; COS-7 cells) shows Affinity of various α1-AR ligands with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively[1].
BODIPY FL prazosin (100 nM, 30 min) can be used as molecular probe for the Visualization of the non-adrenoceptor binding site of α1-adrenergic drugs in erythroleukemia cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

563.41

Formula

C28H32BF2N7O3

CAS No.
SMILES

O=C(CCC1=CC=C2C=C3C(C)=CC(C)=[N]3[B+3]([F-])([N-]21)[F-])N4CCN(CC4)C5=NC6=C(C=C(C(OC)=C6)OC)C(N)=N5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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BODIPY FL prazosin
Cat. No.:
HY-D1606
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