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Cat. No.: HY-P82463A

ATP6V0D1 Antibody (YA2208)(PBS only)

Name: ATP6V0D1 Antibody (YA2208)(PBS only)
Brand: MedChemExpress
SKU: HY-P82463A
Availability: PreOrder

(Synonyms: P39; VATX; VMA6; ATP6D; ATP6DV; VPATPD)

ATP6V0D1 Antibody (YA2208) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP6V0D1.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FC FC: Flow Cytometry	IP IP: Immunoprecipitation
Dilution Ratio	1:500-1:1000	50-1:100	1:100-1:200	1:50-1:100	1:20-1:50

Description

ATP6V0D1 Antibody (YA2208) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP6V0D1.

Host Rabbit
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 40 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 40 kDa

Immunogen

Recombinant protein of human ATP6V0D1 aa1-351.

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

ATP6V0D1 is a Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium^[1]^[2]^[3].
Subcellular Localization

Membrane; Peripheral membrane protein; Cytoplasmic side; Lysosome membrane; Peripheral membrane protein; Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein
Expression

Tissue_specificity:Ubiquitous
Subunit

V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (PubMed:33065002).
SwissProt ID

P61421
Gene ID

9114 [NCBI]
Synonyms

P39; VATX; VMA6; ATP6D; ATP6DV; VPATPD
Research Field

Signal Transduction