1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
    5-HT Receptor
  3. OPC-14523 free base

OPC-14523 free base 

Cat. No.: HY-116594
Handling Instructions

OPC-14523 free base is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 free base shows antidepressant-like activity.

For research use only. We do not sell to patients.

OPC-14523 free base Chemical Structure

OPC-14523 free base Chemical Structure

CAS No. : 145969-30-8

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of OPC-14523 free base:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

OPC-14523 free base is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 free base shows antidepressant-like activity[1][2].

IC50 & Target[1]

sigma 1

47 nM (IC50)

sigma 2

56 nM (IC50)

5-HT1A Receptor

2.3 nM (IC50)

In Vivo

OPC-14523 free base (0.3-100 mg/kg; p.o.; daily for 0, 2, 4, 7 days) produces a marked antidepressant-like effect in the forced swimming test (FST) with rats and mice without affecting the general locomotor activity[1].

Animal Model: Wistar strain of rats (140-245 g)[1]
Dosage: 0.3-100 mg/kg
Administration: P.o.; daily for 0, 2, 4, 7 days
Result: A single doses of 1 mg/kg and higher of OPC-14523 reduced immobility time in the FST with an ED50 value of 27 mg/kg. The ED50 value for OPC-14523 on day 7 was 18 mg/kg.
Animal Model: ICR strain of mice (25-45 g)[1]
Dosage: 0.3-100 mg/kg
Administration: P.o.; daily for 0, 2, 4, 7 days
Result: A single oral dose of OPC-14523 produced a marked reduction in immobility time during the FST at oral doses of 1 mg/kg and higher, with an ED50 value of 20 mg/kg. The potency of OPC-14523 in decreasing immobility time was greater after treatment for seven consecutive days, producing an ED50 value of 2 mg/kg.
Molecular Weight

413.94

Formula

C₂₃H₂₈ClN₃O₂

CAS No.

145969-30-8

SMILES

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)C4=C(C(OC)=CC=C4)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

OPC-14523OPC14523OPC 14523Sigma Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorantidepressantaffinityreuptakeimmobilityswimmingsubtypeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
OPC-14523 free base
Cat. No.:
HY-116594
Quantity:
MCE Japan Authorized Agent: