L-797591 hydrochloride

Name: L-797591 hydrochloride
Brand: MedChemExpress
SKU: HY-125382A
Rating: 4.5 (1 reviews)

Cat. No.: HY-125382A Purity: 99.81%: Data Sheet
COA

SDS
Handling Instructions
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L-797591 hydrochloride is a selective sst₁ agonist. L-797591 hydrochloride mimicks the effects of SRIF-14 and SRIF-28 by potently inhibiting either Forskolin (HY-15371)-stimulated or CRH-stimulated cAMP accumulation.

For research use only. We do not sell to patients.

L-797591 hydrochloride Chemical Structure

CAS No. : 3026641-74-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-797591 hydrochloride:

L-797591 Get quote

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•Related Small Molecules:

•Related Proteins:

View All Somatostatin Receptor Isoform Specific Products:

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

SSTR1

In Vitro

L-797591 (10^-7 M) hydrochloride inhibits Forskolin-stimulated cAMP accumulation in cortical neuron monolayers^[1].
L-797591 (1 μM; 1 h) hydrochloride inhibits CRH-stimulated cAMP accumulation in E17-18 cortical neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

644.29

Formula

C₃₈H₅₀ClN₅O₂

CAS No.

3026641-74-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C([C@@H](CC1=C2C=CC=CC2=CC=C1)NC(N(CCC3=NC=CC=C3)CCC4=CC=CC=C4)=O)NCC(C)(CC(CCN)C)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 55 mg/mL (85.37 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5521 mL	7.7605 mL	15.5210 mL
5 mM	0.3104 mL	1.5521 mL	3.1042 mL
10 mM	0.1552 mL	0.7760 mL	1.5521 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.81%

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Data Sheet (271 KB) SDS (252 KB)

COA (249 KB) HNMR (151 KB) RP-HPLC (116 KB) LCMS (120 KB)

Handling Instructions (2659 KB)

References

[1]. Blake AD, et al. Somatostatin receptor subtype 1 (sst(1)) regulates intracellular 3',5'-cyclic adenosine monophosphate accumulation in rat embryonic cortical neurons: evidence with L-797,591, an sst(1)-subtype-selective nonpeptidyl agonist. Neuropharmacology. 2001;40(4):590-596. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5521 mL	7.7605 mL	15.5210 mL	38.8024 mL
	5 mM	0.3104 mL	1.5521 mL	3.1042 mL	7.7605 mL
	10 mM	0.1552 mL	0.7760 mL	1.5521 mL	3.8802 mL
	15 mM	0.1035 mL	0.5174 mL	1.0347 mL	2.5868 mL
	20 mM	0.0776 mL	0.3880 mL	0.7760 mL	1.9401 mL
	25 mM	0.0621 mL	0.3104 mL	0.6208 mL	1.5521 mL
	30 mM	0.0517 mL	0.2587 mL	0.5174 mL	1.2934 mL
	40 mM	0.0388 mL	0.1940 mL	0.3880 mL	0.9701 mL
	50 mM	0.0310 mL	0.1552 mL	0.3104 mL	0.7760 mL
	60 mM	0.0259 mL	0.1293 mL	0.2587 mL	0.6467 mL
	80 mM	0.0194 mL	0.0970 mL	0.1940 mL	0.4850 mL