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Cat. No.: HY-100926

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MDL 72832 hydrochloride

MDL 72832 (hydrochloride) is a 2,3-dihydro-1,4-benzodioxane derivative and a 5-HT₁a receptor ligand with high affinity for the 5-HT₁a receptor.

For research use only. We do not sell to patients.

CAS No.: 113777-40-5
Formula: C₂₂H₃₁ClN₂O₄
Molecular Weight:422.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MDL 72832 hydrochloride Chemical Structure

CAS No.: 113777-40-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

MDL 72832 (hydrochloride) is a 2,3-dihydro-1,4-benzodioxane derivative and a 5-HT₁a receptor ligand with high affinity for the 5-HT₁a receptor.

All 5-HT Receptor Isoforms :

In Vitro

MDL 72832 (hydrochloride) displays high affinity for 5-HT₁A receptors (pK_i = 9.1) and lower affinity for other tested serotonin, adrenergic, and dopaminergic receptor subtypes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MDL 72832 (hydrochloride) (0.1 mg/kg; s.c.; single dose) induces lower lip retraction in male rats with an ED₅₀ of 0.1 mg/kg via subcutaneous administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

male, 180-350 g^[1]
Dosage:

0.1 mg/kg
Administration:

s.c.; single dose
Result:

Produced a lower lip retraction response with an ED₅₀ of 0.1 mg/kg s.c.

Chemical Information

CAS No. 113777-40-5
Molecular Weight 422.95
Formula C₂₂H₃₁ClN₂O₄
SMILES

O=C1N(CCCCNCC2OC3=C(OC2)C=CC=C3)C(CC4(CCCC4)C1)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Comoy C, et al. Synthesis of various analog derivatives of ORG13514 as 5-HT1A ligands. Farmaco. 1999;54(11-12):791-799. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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