Synthesis of various analog derivatives of ORG13514 as 5-HT1A ligands

  • Farmaco. 1999 Nov-Dec;54(11-12):791-9. doi: 10.1016/s0014-827x(99)00106-8.
C Comoy  1 ,  A Benarab ,  M Leinot ,  A Monteil ,  G Guillaumet
Affiliations
  • 1. Institut de Chimie Organique et Analytique, associé CNRS, Université d'Orléans, France. [email protected]
PMID: 10668181 DOI: 10.1016/s0014-827x(99)00106-8
Abstract

In connection with the development of new potential 5-HT1A ligands, multistep synthesis of N-substituted-3-aminomethyl-2,3-dihydro-1,4-dioxinol[2,3-b]pyridin e derivatives as ORG13514 analogs are described. Their biological activity as 5-HT1A type ligands is reported and compared with ORG13514 affinity and selectivity for 5-HT1A receptors.

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